I'm a believer in one highway = one designation. If a U.S. route uses an interstate concurrently for a relatively short distance before taking off in another direction, then that's one thing - for example, U.S. 71 on I-29 north of Kansas City. That only covers about 70 miles. But, U.S. 52 on I-94 in North Dakota and Minnesota for 340 miles with no independent segment of its own, I think that's too long. The U.S. 52 segment in North Dakota really has no continuity with the segment in Minnesota. Now, if you were to propose replacing U.S. 10 in Minnesota with 52, thus reducing the concurrency to 90 miles or so in North Dakota, I might think differently about it.
I also disagree with using Interstate-concurrent U.S. routes as business routes, either posted as Business (U.S. Route) like Kansas or as the mainline. Nothing wrong or difficult to understand with an interstate business route, since by definition that is a surface street that (usually) provides a loop through an urban area. But, how much do through travelers really use business routes, especially in larger towns? Travel-oriented business have largely relocated from main streets to locations near and visible from freeways, because that's where the business is coming from.
The interstate system has created numbering redundancies, but this is an opportunity to fine tune some of the U.S. highway system to correct some awkward routings imposed in the 1920s and 1930s. Maybe that's another thread altogether...