IMHO, US-50 was way too far north for I-64, too close to I-70. Even now, I-64 could still be a bit further south. The current route doesn't go near much other than Mount Vernon, away from the main population center of Egypt (that being Marion, Herrin, and Carbondale).
Personally, I'd have routed it south of US-460 toward Pickneyville, Herrin, West Frankfort, and then due east to Evansville.
(Any more, and it's over to Fictional Highways.)