No, I don't think malls are going away, just poorly placed and poorly anchored ones. Wal-Mart kind of sucks for any real sort of quality, and it is usually the bottom of the barrel around here, excluding K-Mart. Their prices aren't all that good. Meijer, Ultra Foods (Central Foods Coop), and Food4Less (Kroger) have better typical food prices with better quality, and even Dominick's (Safeway) can beat Wal-Mart's sales. On the clothing end, JCPenney, Carson's, Target, and Kohl's have Wal-Mart beat for value with better quality for the dollar. Wal-Mart's only really good for some electronics, some hard goods, and a few other odds and ends. Wal-Mart kind of reminds me of K-Mart of the 1980s or Montgomery Ward of the 1990s. When they crash, it's going to be hard.
As for malls, I say that they aren't going away as the established ones seem to be doing fairly well around here. In fact, the local one is up over 95% occupancy. Stores go out of their way to look for a space around the mall, or in the mall.
Sorry to see your 24 hour drug stores coming to an end in Kissimmee, FL, but that must be a local thing down there. CVS hasn't opened too many around Chicago, but Walgreen's basically owns the 24 hour market. As for video, Blockbuster is a victim of its own excesses. Too many small stores and silly pricing strategies. Family Video around here is still going very strong.