Throw in the fact that Cline Ave goes through shady neighborhoods.
Without a doubt. Now, there are exits to decent areas, such as 169th Street (NOT 15th Avenue) and U.S. 12 (Columbus Drive). Otherwise, I'd only use Cline as a quick shortcut to Chicago...before the Indiana Harbor bridge was condemned. Now, you must be cautious.
Indiana 49 (between U.S. 30 and the Toll Road) is known to have some flak, as well. There's a set of hard banking curves just south of the U.S. 6 interchange, and I remember reading an article where a trucker died for under-correcting one of those curves and crashing off-road. The at-grade intersections further south have had their fair share of fatal accidents, and then there's Vale Park Road (County Road 400 N).
When it was a lighted intersection, it was a statistical nightmare. I just read today that in 2 years (2008-2010), that intersection saw 103 vehicles involved in 54 accidents, resulting in 24 injuries and 2 deaths. After using staggered lights (all red for all directions for 5 seconds or more) and flashing lights to warn drivers of the impending signal - with failed results, they started work this month to turn it into a full-fledged diamond-roundabout interchange.
I wouldn't be surprised if they decided to make the stretch between U.S. 6 and U.S. 30 all freeway in a few years from now.