Most and/or biggest buildings between opposite directions of a divided highway?

[Flint1979]

Of current roads, I-75 just north of Cincy has a city neighborhood between the NB and SB lanes - several blocks, houses, businesses, etc

Link to Arlington Heights, Ohio. The entire city (or village as Ohio defines it) is located within the median of I-75. Definitely the best example I know of:
https://goo.gl/maps/7F2ZkQEcLjEvGNR69

Lockland borders it to the north and is also within the median of I-75. Although Lockland extends to the other side of the highway while Arlington Heights is basically in the highway median.

[LilianaUwU]

QC 175 in Saint-Roch has multiple city blocks between its two directions.

https://www.google.com/maps/@46.8144108,-71.22711,1050m/data=!3m1!1e3?hl=en

[Henry]

The surface section of I-78 in Jersey City is yet another one. Why it doesn't just end at NJ 139 is beyond me.

https://www.google.com/maps/@40.7313668,-74.0430805,1309m/data=!3m1!1e3?hl=en

[ilpt4u]

The surface section of I-78 in Jersey City is yet another one. Why it doesn't just end at NJ 139 is beyond me.

https://www.google.com/maps/@40.7313668,-74.0430805,1309m/data=!3m1!1e3?hl=en

I was under the impression that I-78 continues as One-Way pair surface streets, into the Holland Tunnel, under the Hudson River, and into Lower Manhattan, basically to make sure the Tunnel is part of the Interstate System. I could be very wrong on that. I'll let the Native NYers/NJans around here add if there is more to it than that

[jp the roadgeek]

PA 272 in Willow Street has a shopping plaza in the middle (southbound lanes are on the other side of the plaza).

[kphoger]

These aren't "medians".  These are just city blocks.

[vdeane]

The surface section of I-78 in Jersey City is yet another one. Why it doesn't just end at NJ 139 is beyond me.

https://www.google.com/maps/@40.7313668,-74.0430805,1309m/data=!3m1!1e3?hl=en

I was under the impression that I-78 continues as One-Way pair surface streets, into the Holland Tunnel, under the Hudson River, and into Lower Manhattan, basically to make sure the Tunnel is part of the Interstate System. I could be very wrong on that. I'll let the Native NYers/NJans around here add if there is more to it than that

I-78 was supposed to continue east across expressways that were never built down to JFK, and then turn north up the Clearview (both built and unbuilt) over what is now I-295 (and I want to say I-695 as well) back up to I-95.  There was no effort to keep the Lincoln in the interstate system when I-495 across Manhattan was cancelled, so I'm not sure why they would with the Holland... my guess is that they just never thought about it that far.

[Henry]

The surface section of I-78 in Jersey City is yet another one. Why it doesn't just end at NJ 139 is beyond me.

https://www.google.com/maps/@40.7313668,-74.0430805,1309m/data=!3m1!1e3?hl=en

I was under the impression that I-78 continues as One-Way pair surface streets, into the Holland Tunnel, under the Hudson River, and into Lower Manhattan, basically to make sure the Tunnel is part of the Interstate System. I could be very wrong on that. I'll let the Native NYers/NJans around here add if there is more to it than that

I-78 was supposed to continue east across expressways that were never built down to JFK, and then turn north up the Clearview (both built and unbuilt) over what is now I-295 (and I want to say I-695 as well) back up to I-95.  There was no effort to keep the Lincoln in the interstate system when I-495 across Manhattan was cancelled, so I'm not sure why they would with the Holland... my guess is that they just never thought about it that far.

I've read about that many times. As to why it runs on those one-way streets, I'm being led to believe that a freeway was planned to run in between said streets which would serve as frontage roads, and Jersey City opposed it.

[triplemultiplex]

These aren't "medians".  These are just city blocks.

Potato - potato.

[golden eagle]

Before Mississippi legalized the lottery, I used to drive to Tallulah, LA to buy lottery tickets (because it was off the beaten path). The Citgo station is in the divided space between the US65 northbound and southbound lanes.