So, after last December's Greyhound trip to St. Louis was successful I've decided to do it again. Looks like the route is as follows:
Mass Pike to 84
84 to CT 15
CT 15 to I-91
91 to 95
95 to 278
Surface roads (Second Av.-42nd Street in NYC)
NJ 495 to NJTPK
NJTPK to NJ 70
Philadelphia
I-76 to I-376
Pittsburgh
I-70 to Columbus
Columbus- Indianapolis via I-70
Indy to St. Louis via I-70 and 55.
Anything I have to look out for? Hopefully it won't rain this time. Left BOS at 10 AM last year and am catching the same bus.