To me, the unqualified term "decommission" implies a complete and total removal of a highway number from the network in its current form. Moving the highway designation to a different physical road doesn't count (that's a realignment), and neither does the removal of a portion of the highway (that's a truncation).
Using that definition, it's hard to see where a two-digit Interstate highway designation realistically has a chance of being removed. Plenty of 2-digit US routes have be decom'd over the years, but those are an entirely different animal, since most of those were due to being replaced by Interstate highways. That situation would only apply to the Interstates if a higher class of road were introduced above them, which seems unlikely.
I suppose conditions could develop where one of the shorter single-state routes could be given the axe, like I-97. If the financial well-being or transportation strategy of North Carolina changes, I could see unbuilt projects there getting cancelled, and that could then lead to things like I-73, I-74, I-42, etc. getting decommissioned since it would be impossible for them to fulfill the function they were designed to fill as part of the system.