I was surprised to see the amount of radioactive material that is allowed over the CBBT. This may be because medical isotopes needed on the Eastern Shore come from Norfolk, etc. and it would be prohibitively expense to have to transport these (generally) short-lived materials by helicopter or plane. Also residual radioactive waste of the longer-lived materials would be headed to locations not in the Northeast. The limitation for them would be the 500 pounds CBBT threshold. 300 Curies is a large quantity of radioactive material (in terms of how many atoms are decaying per second, not its mass - 300 Curies of Radium-226 would be just 300 g of actual material) and medical radioactive waste is quite unlikely to be anywhere near that much. The mass comes from objects that have/ may have come into contact with the radioactivity (gloves, gowns, tubes, etc.)
By contrast, the Baltimore tunnels disallow any amount (not sure about amounts considered exempt from DOT and/or NRC regulations) of any radionuclide. This is overly restrictive because many of the radioactive materials that would use the tunnels (lots of hospitals that use medical isotopes) are in tiny amounts relative to any harm they could do and they often have very short half-lives.