There's 2 sides to the numbering debate in my opinion:
1). The number doesn't matter as long as it's unique in the region that it runs and is near what it should be for a standardized grid numbering scheme. What's more important is that it's built to the standards that allow for freer and faster flowing traffic with appropriate geometry, lane, and shoulder widths as well as a somewhat higher floor of maintenance standards. You don't want to burn a number that might logically fit somewhere else.
2). The number matters in that the currently designated endpoints aren't necessarily the ultimate endpoints, although they might be for 3-4 decades, and part of having an Interstate designation is marketing your area for industrial and commercial growth, so the number might have an impact from a marketing perspective. You don't want to pigeonhole your possibilities to extend the termini with future growth that the facility might induce near the endpoints, nor preclude the possibility that growth to other logical termini past the current endpoints might warrant extending the facility.
I would lean toward the latter view. The growth patterns according to the census data show that every county to the east of I-49 is on a growth trajectory until you get to the bootheel, whereas west of I-35, it isn't. I could easily see I-4*/50 growing past NWA to the east as the area along US-412 is prime retirement area and will continue its growth as the boomers wind down their work lives. There's plenty of justification for extending at minimum to US-65 at Harrison in the next 15 years, but also to I-57 after it's completion not long afterwards with all of the counties in between continuing to grow. And other than the counties on both sides the Mississippi River, all of the counties between there and Nashville are growing. The question ultimately is, where else does I-50 belong, if not along US-412? What are the growth prospects of any alternative across multiple states? Kansas looks pretty bleak to me, as does southern Illinois and eastern Kentucky.
