Folks have touched on this item, but I think it bears further explanation.
East of the Mississippi pre-1950, the US had much more of the population than west of the Mississippi, and there was a greater demand earlier for road building. Many of the important US highways were built out before the development of high-speed roadway design standards, including access management. These routes would not be suitable for later in-place upgrades to Interstate-standard freeway.
Road funding was also less free-flowing, partially due to the Great Depression and WWII, so what improvements were made were done with a short-term mindset rather than with considerations 50 or 100 years down the road. Therefore, there generally was no simple widening of important US routes; typically they were supplanted by tollways like the Pennsylvania Turnpike, Indiana Toll Road, or New Jersey Turnpike, or later by a federally-funded Interstate highway.
Out west, those tollway/Interstate highway improvements came later on, and more sparsely, than out east. However, they also were later to the game with highway improvements in general. At that point, those US routes not supplanted by Interstates were being built out to more modern standards, including more gradual curves (both horizontal and vertical), wider Right-of-Way, and more room for later widening as needed. The fact that there were fewer homes/farms/businesses encroaching on the ROW needed to begin with facilitated use of these modern standards, and there were fewer NIMBYs to have to appease to get a road built. These differences allowed higher speed limits to allow people to safely reach their more far-flung destinations faster, in many cases on par with a comparable Interstate highway.