I have a feeling the a reroute around Refugio will be the final piece of the I-69E branch. Refugio is a major stopping town for rest, refueling, dining, etc. I believe they will get to Woodsboro, Odem, and Riviera before Refugio. Riviera is also the last stopping town for drivers southbound on US-77 (they won't see anything for almost 60 miles later in Raymondville). Until the last couple of decades, it used to be that Kingsville was that last stopover until Raymondville (72-mile stretch). Towns like Ricardo and Woodsboro might not need a bypass around it since it's already four-lanes right through those towns; just need a couple of overpasses in each town.
As for I-69C, a bypass around Premont would be the only thing left along US-281. Reroutes around Alice, Falfurrias, and Encino have already been done long ago.