All of I-35 between Main Street and Indian Hills Road was just widened around 2010 or so. It remains free-flowing even during rush hour, so I don't really think there's much of a need to touch the mainline.
The section between N. 12th St. and S. 19th St. in Moore could use some geometry adjustments. There's a few ramps around that area that don't have much merging room. Another thing that might be discussed is an interchange at S. 34th Street—a bridge over the interstate to connect the road and relieve traffic on Indian Hills is already planned, and the Moore government is interested in having an interchange there.
The only thing I could see being discussed in the Norman segment of this is the possibility of converting the frontage roads to one-way. Currently, they are two-way, with one lane going in each direction. It works, sort of. The southbound frontage road's connection to Main St. is horrifically awkward, and that really needed to be addressed long ago. Also, with further development in the University Town Center development, there will likely be a need to extend the service road on the east side of the highway further north.