My sister is moving to State College to take classes in Penn State University. We'll be hauling a trailer, so the route you guys suggest should be the least mountainous as possible.
Our route (if we are driving) will pretty much be I-81 to US 322. It's all freeway, and it shouldn't be too bad in terrain. The only non-freeway segments we'll be on is surface streets and a 1 mile stretch of US 322.
Feel free to suggest routes, and I'll tell them to my dad for us to try.
Just be sure to get some ice cream at the Berkey Creamery.