Because we need one more of these, right?
Instead of the traditional N/S/E/W groupings, I decided to use Even-North, Even-South, Odd-East, and Odd-West. I just went by the 16 longest in each category as listed in Wikipedia, so if your favorite isn't included, blame Wikipedia.
Even-North
US 20 vs US 220
US 26 vs US 36
US 12 vs US 18
US 40 vs US 29
US 6 vs US 10
US 24 vs US 14
US 30 vs US 212
US 2 vs US 34
Even-South
US 50 vs US 78
US 82 vs US 90
US 64 vs US 80
US 62 vs US 278
US 60 vs US 190
US 84 vs US 160
US 70 vs US 98
US 52 vs US 54
Odd-East
US 1 v US 231
US 45 vs US 51
US 11 vs US 301
US 23 vs US 17
US 41 vs US 441
US 27 vs US 63
US 59 vs US 421
US 19 vs US 31
Odd-West
US 87 vs US 75
US 71 vs US 101
US 281 vs US 77
US 191 vs US 93
US 83 vs US 89
US 67 vs US 85
US 287 vs US 395
US 95 vs US 61
Even-North
US 20 vs US 220
US 26 vs US 36
US 12 vs US 18
US 40 vs US 29
US 6 vs US 10
US 24 vs US 14
US 30 vs US 212
US 2 vs US 34
Even-South
US 50 vs US 78
US 82 vs US 90
US 64 vs US 80
US 62 vs US 278
US 60 vs US 190
US 84 vs US 160
US 70 vs US 98
US 52 vs US 54
Odd-East
US 1 v US 231
US 45 vs US 51
US 11 vs US 301
US 23 vs US 17
US 41 vs US 441
US 27 vs US 63
US 59 vs US 421
US 19 vs US 31
Odd-West
US 87 vs US 75
US 71 vs US 101
US 281 vs US 77
US 191 vs US 93
US 83 vs US 89
US 67 vs US 85
US 287 vs US 395
US 95 vs US 61
Even-North
US 20 vs US 220
US 26 vs US 36
US 12 vs US 18
US 40 vs US 29
US 6 vs US 10
US 24 vs US 14
US 30 vs US 212
US 2 vs US 34
Even-South
US 50 vs US 78
US 82 vs US 90
US 64 vs US 80
US 62 vs US 278
US 60 vs US 190
US 84 vs US 160
US 70 vs US 98
US 52 vs US 54
Odd-East
US 1 v US 231
US 45 vs US 51
US 11 vs US 301
US 23 vs US 17
US 41 vs US 441
US 27 vs US 63
US 59 vs US 421
US 19 vs US 31
Odd-West
US 87 vs US 75
US 71 vs US 101
US 281 vs US 77
US 191 vs US 93
US 83 vs US 89
US 67 vs US 85
US 287 vs US 395
US 95 vs US 61
Really, another highway challenge? I'll join in...
My picks are:
EVEN-NORTH
US 20
US 36
US 12
US 40
US 6
US 24
US 30
US 2
EVEN-SOUTH
US 50
US 90
US 64
US 278
US 60
US 160
US 70
US 52
ODD-EAST
US 1
US 51
US 301
US 17
US 41
US 27
US 421
US 19
ODD-WEST
US 87
US 101
US 77
US 191
US 83
US 85
US 395
US 61