7th Avenue in Ybor City since it's inception in 1885 essentially served the main street of the neighborhood. Notably parts of 7th Avenue would even be incorporated into several of the shifting alignments of US Route 541 as it transitioned from downtown Tampa through the Ybor City neighborhood. 7th Avenue from 22nd Street eastward was used for a time as segments of Florida State Road 60 and Florida State Road 574.
https://www.gribblenation.org/2021/07/exploring-7th-avenue-in-ybor-city-and.html