https://goo.gl/maps/EWocg58CjYFw17d7A
Here is the Welcome Center in Savannah, GA that is on the SE Corner of Boundary Street and Oglethorpe Avenue. This, as you can see by the orange roof that this used to be a Howard Johnson Restaurant.
I remember back in the seventies when the restaurant also had a motor lodge behind it. Boundary Street then was US 17 ALT and the restaurant fronted the former US route at the entrance to the Eugene Talmadge Bridge. Oglethorpe Avenue had a T intersection with Boundary and the bridge. There was even a three lane toll plaza to collect fare to cross the original two lane Talmadge Bridge just north of Oglethorpe.
Of course the restaurant and motor lodges of Ho Jo are relics of the past, but in many places can still be found if you know what to look at.
Any other buildings today that were something else in the past? Don't have to be Howard Johnson's.
Dept restaurant in Green Bay was as you could have guessed, an old CNW train depot.