Highways with the most former designations?

[national highway 1]

This stretch of Pennant Hills Rd (Cumberland Hwy) around the corner from where I live has had quite a lot of route number changes over the past 50 years.
http://goo.gl/maps/VBrcF
Ring Road 5 (1964-1974)
State Route 55 (1974-1988)
State Route 77 (1988-1993)
Metroad 7 (1993-2005)
Metroad 6 (2005-2013)
A28 (2013-)

[bugo]

J Street in Mojave between the Mojave-Barstow Highway and the north Route 14 junction:

Route 7 (1934-1936)
US 466 (1935-1964)
US 6 (1936-1964)
Route 58 (1964-2004)
Route 14 (1964-present)
Business Route 58 (2004-present)

Overlaps are cheating. Otherwise I-465 around Indy beats that.

Former designations.  As in the highway has one number at a time.  The Muskogee-Wagoner example is kind of cheating, as I don't think OK 2 was ever the sole number on this highway.

[PHLBOS]

Interstates would also count but I doubt there are any that would be any eligible for this thread.

Because of the historical swaps between I-70, I-76, I-79 and their 3DIs in Pittsburgh probably set PA's record for most designations on the Parkway West between the Fort Pitt Tunnel and roughly current I-79

PA 28 (1951-1961)
I-70 (1960-1964)
I-79 (1964-1972)
I-76 (1972-1973)
I-279 (1973-2009)
I-376 (2009-present)

briantroutman gave an example.

Wilbur Cross Highway in MA (& CT northeast of E. Hartford):

MA 15* => I-84 => I-86 => I-84 again.

*the MA 15 designation lingered for a bit when the highway became an Interstate.

[CNGL-Leudimin]

Wow, some examples are crazy. In Europe most roads keep their number for a long time. But still, I can name a couple Spanish roads that have got at least three designations over the years:

Strecht of road from Zaragoza towards the North: N-123/N-330 -> N-330 -> A-23 -> N-330 again. Also E07 until A-23 got realigned.
Zaragoza Northern bypass: A-2 (Would be AP-2 now) -> N-II -> Current A-2, which got overlaid by Z-40. Also E90, and I don't know if it got a number in the former E route numbering.

[Rover_0]

How about US-191 between Monticello and Crescent Junction in Utah? It's not the most, but it's always been a US Route:

US-450 (1926-1939)
US-160 (1939-1970)
US-163 (1970-1981)
US-191 (1981-Present)

Not unlike US-491 from Monticello to Cortez:

US-450 (1926-1939)
US-160 (1939-1970)
US-666 (1970-2003)
US-491 (2003-Present)

[bugo]

I don't consider US 491 a legitimate US route, so it's still 666 to me.  191 south of I-40 is also still US 666 to me.

[sdmichael]

The Arroyo Seco Parkway between the Four-Level and approximately I-5 in Los Angeles...

US 6 (1943-1964)
US 66 (1943-1964)
US 99 (1940s to 1959?)
Route 11 (1951?-1981)
Route 110 (1981-present)

Actually, US 6, US 66, US 99, and SR-11 were all on the Arroyo Seco Parkway from 1939 not 1943.