South Carolina Highway 46 runs 17.33 miles east from U.S. 321 (Deerfield Road) at Hardeeville in Jasper County to U.S. 278 (Fording Island Road) at Bluffton in Beaufort County.
S.C. 46 follows Main Street through the Hardeeville city center southeast onto Plantation Drive. Turning east along Okatie Highway, S.C. 46 overlaps with S.C. 170 for 2.37 miles to a roundabout with Mary River Road and New Riverside Road south into the New Riverside development. S.C. 170 (Okatie Highway) turns northeast while S.C. 46 lines May River Road east from Pritchardville into the town of Bluffton. The eastern leg of S.C. 46 takes Bluffton Road north from the Bluffton town center to U.S. 278 across from Waterford Drive into The Crescent golf course community.
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| S.C. 46 (Church Road) enters the Hardeeville city limits just ahead of Sanders Road (Road 292) and an at-grade crossing with the CSX Railroad. 03/15/10 |
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| S.C. 46 (Main Street) east next intersects U.S. 17 (Whyte Hardee Boulevard). 01/05/19 |
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| U.S. 17 heads south from Interstate 95 in Hardeeville to the Eugene Talmadge Memorial Bridge across the Savannah River into Savannah, Georgia. U.S. 17 north parallels I-95 to Ridgeland before turning east to Charleston. 01/05/19 |
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| Confirming marker posted along Main Street east of U.S. 17. 01/05/19 |
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| Interstate 95 spans S.C. 46 (Main Street) without direct access southeast of Hardeeville City Hall. Frontage Road (Road 421) runs 0.70 miles southwest to the exchange joining I-95 and U.S. 17. 01/05/19 |
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| S.C. 46 (Plantation Drive) plies southward across Horse Swamp. 01/05/19 |
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| S.C. 46 combines with S.C. 170 (Okatie Highway) east to Pritchardville. 01/05/19 |
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| Okatie Highway extends south along S.C. 315 from S.C. 170 west nearby to Levi and U.S. 17 north of Savannah, Georgia. S.C. 46/170 overlap east into the town of Bluffton. 01/05/19 |
Page Updated 12-05-2022.
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