Travelimg nationally between Florida and Indiana, U.S. 27 constitutes a 356 mile route through the west side of Georgia. Doubling as State Route 1, U.S. 27 connects the cities of Bainbridge, Blakely, Columbus, LaGrange, Carrollton, Cedartown, Rome, Summerville and La Fayette. While most of U.S. 27 consists of a four-lane, divided highway, some sections remain rural with just two lanes.
U.S. 27 (Tallahassee Highway) meets U.S. 84 at a diamond interchange on the south side of Bainbridge. The two overlap along a freeway northwest around Downtown and across the Flint River to West Bainbridge. U.S. 27 Business, approved by the American Association of State Highway Officials (AASHO) on October 14, 1967 along with the relocation of U.S. 27 onto the SR 38 Loop (U.S. 84) freeway, navigates through the Bainbridge street grid to Downtown. U.S. 27 Business takes Scott Street north, Shotwell Street (U.S. 84BU) west, Broad Street north and Dothan Road west across the city.
U.S. 27/280 overlap 16.94 miles northwest from Wells Street in Cusseta to the Columbus Civic Center south of Downtown Columbus. The two routes originally met at Broad and Wells Street in the Cusseta city center. A four-lane bypass opened by 1974 to the south, shifting both routes away from town. The relocation was approved by AASHO on November 16, 1974.
The section of U.S. 27 between Fort Benning / Columbus and Interstate 85 at LaGrange is superseded by Interstate 185. U.S. 27 Alternate loops east from Columbus to Greenville and Newnan, returning to its parent 91.32 miles to the north at Carrollton.
U.S. 27 shifts onto a 3.4 mile bypass of Lafayette. This realignment was approved by the American Association of State Highway and Transportation Officials (AASHTO) on December 12, 1988. The change also included redesignating the former route through the city as U.S. 27 Business.