U.S. 50 shares substantial portions of its alignment across the Beehive State with other numbered highways. This includes an 89.40 mile overlap with U.S. 6 from the Ferguson Desert and Nevada state line to Sevier Valley and the city of Delta, a 10.09 mile concurrency with Interstate 15 from Holden to Scipio, a 1.765 mile overlap with U.S. 89 through Salina, and 174.94 miles with I-70 to the Colorado state line.
The first independent section of U.S. 50 angle southeast across the Pahvant Valley between Delta and Holden. Branching south from I-15, the second portion runs between the Pahvant Range and Valley Mountains to Scipio Lake and the Sevier County line. Turning east across the Valley Mountains, U.S. 50 reaches Salina where it combine with U.S. 89 south to Interstate 70.