West
U.S. 278 (Independence Boulevard) meets Interstate 95 at a diamond interchange (Exit 8) in the city of Hardeeville.
03/10/22
U.S. 278 combines with U.S. 17 north to the immediate west of Interstate 95 in north Hardeeville.
09/25/22
U.S. 278 overlaps with U.S. 17 north 12.80 miles to 3rd Street in Ridgeland. U.S. 17 (Whyte Hardee Road) south heads 16.00 miles to the Georgia state line across the Savannah River.
12/31/17
North West
09/16/21
09/16/21
09/16/21
09/16/21
U.S. 278 separates from U.S. 17 (Jacob Smart Boulevard) north in Ridgeland along 3rd Avenue. U.S. 17 combines with I-95 north in 1.57 miles.
08/14/21
West
03/10/22
3rd Avenue west at Green Street (Road 32) in Ridgeland.
03/10/22
S.C. 336 Connector ties into U.S. 278 (Grays Highway) north along Russell Street ahead of this reassurance marker in Ridgeland.
03/10/22
03/10/22
03/10/22
03/10/22
S.C. 652 (Calf Pen Bay Road) branches 10.48 miles northwest from U.S. 278 to U.S. 601 (Cypress Branch Road) at Pineland.
03/10/22
03/10/22
U.S. 278 (Grays Highway) heads north from S.C. 652 to combine with S.C. 462 at Morgandollar Road.
03/10/22
West
The 0.82 mile long overlap with S.C. 462 is unmarked along U.S. 278 westbound.
03/10/22
03/10/22
S.C. 462 separates with U.S. 278 (Grays Highway) along Gillison Branch Road 12.80 miles west to U.S. 321 at Robertville.
03/10/22
West
03/10/22
03/10/22
03/10/22
03/10/22
S.C. 3 (Heritage Road) loops west from U.S. 278 to Estill and north back to U.S. 278 near Barnwell.
03/10/22
03/10/22
03/10/22
U.S. 278 (Grays Highway) westbound at Cat Branch Road (Road 108).
03/10/22
U.S. 278 (Grays Highway) enters Hampton County just north of Cat Branch Road.
03/10/22
03/10/22
03/10/22
03/10/22
U.S. 278 (Grays Highway) converges with the west end of S.C. 68 (Yemassee Highway) at Almeda.
03/10/22
S.C. 68 bee lines southeast 15.33 miles to U.S. 17 ALT/21 in the town of Yemassee.
03/10/22
U.S. 278 (Yemassee Highway) runs alongside a CSX Railroad line northwest from S.C. 68 into the town of Varnville.
03/10/22
U.S. 278 follows Carolina Avenue in Varnville.
03/10/22
The south end of S.C. 68 ties into U.S. 278 (Carolina Avenue) at Main Street and Hickory Hill Road (Road 50) in Varnville.
03/10/22
S.C. 63 travels 25.36 miles east to U.S. 17 ALT in Walternboro.
03/10/22
U.S. 278 (Elm Street) west at W Pulaski Drive.
03/10/22
03/10/22
S.C. 363 (Third Street / Charleston Highway) runs 4.30 miles east from U.S. 278 (Elm Street) in Hampton to S.C. 63 (Walterboro Highway).
03/10/22
West 
North
Lee Avenue leads into historic Downtown Hampton from U.S. 278 (Elm Street).
03/10/22
U.S. 601 heads north from U.S. 321 near Pineland to Furman and into Hampton along 1st Street W.
03/10/22
West North
U.S. 601 overlaps with U.S. 278 (Elm Street) west through Downtown Hampton for 0.60 miles. The two partition just ahead of S.C. 363 (Shaw Drive) west to Luray.
03/10/22
U.S. 601 (Hoover Street) continues north from Hampton to Bamberg and with U.S. 301 into Orangeburg.
03/10/22
S.C. 363 separates from U.S. 278 (Elm Street) along Shaw Drive and Luray Highway west 8.06 miles to U.S. 321 at Luray.
03/10/22
West
03/10/22
03/10/22
03/10/22
U.S. 278 (Augusta Highway) enters the town of Brunson along Railroad Avenue.
03/10/22
03/10/22
03/10/22
03/10/22
03/10/22
U.S. 278 (Allendale-Hampton Highway) converges with U.S. 321 (Hampton Avenue) in the Fairfax business district.
03/10/22
Beginning in Hardeeville, U.S. 321 travels north to Estill and Fairfax en route to Denmark and Columbia.
03/10/22
Confirming marker posted west of U.S. 321 (Hampton Avenue) in the town of Fairfax.
03/10/22
U.S. 278 (Allendale-Fairfax Highway) crosses two CSX Railroad lines at-grade between Pickens Avenue and Sumter Avenue in Fairfax.
09/22/14
A set of flashers operate along U.S. 278 (Allendale-Fairfax Highway) at Boundary Street by Allendale County Hospital.
03/10/22
03/10/22
U.S. 278 west enters the Allendale County seat of Allendale at Park Square Road 387).
03/10/22
U.S. 278 (Allendale-Fairfax Highway) joins U.S. 301 (Main Street) north for five blocks between S.C. 125 (Augusta Highway) and Barnwell Highway through the Allendale business district.
03/10/22
U.S. 301 heads southwest to Sylvania, Georgia.
03/10/22
S.C. 125 travels northwest through the Savannah River Site to U.S. 278 at Beech Island.
11/21/21
S.C. 125 (Augusta Highway) proceeds northwest one block from U.S. 278/301 (Main Street) to Memorial Avenue (Road 8).
01/03/08
West 
North
U.S. 278/301 (Main Street) north at Bay Street in Allendale.
03/10/22
U.S. 278 branches west from U.S. 301 (Main Street) after 0.41 miles.
03/10/22
U.S. 301 continues northeast to U.S. 321 at Ulmer and with U.S. 601 to Orangeburg.
03/10/22
West
The Allendale County Courthouse lies along the north side of U.S. 278 (Barnwell Highway) at Memorial Avenue just west of U.S. 301.
03/10/22
U.S. 278 makes an S-curve across an abandoned Southern Railroad line from Cave Church Road (Road 74).
03/10/22
03/10/22
03/10/22
Continuing north into Barnwell County, U.S. 278 follows Kings Avenue through the town of Kline.
03/10/22
03/10/22
03/10/22
03/10/22
03/10/22
S.C. 300 constitutes an 11.46 mile long highway south to U.S. 301 at Ulmer.
03/10/22
North from Kline, U.S. 278 converges with S.C. 300 and S.C. 3 at succeeding intersections outside Barnwell.
09/22/14
West 
North
S.C. 3 combines with U.S. 278 (Marlboro Avenue) north for 1.24 miles into the city of Barnwell.
03/10/22
03/10/22
03/10/22
U.S. 278 branches west off Marlboro Avenue onto Jackson Street while S.C. 3 leads north to Downtown Barnwell.
03/10/22
S.C. 3 continues north from Barnwell to Blackville and U.S. 321 at Swansea.
03/10/22
West 
North
S.C. 125 combines with U.S. 278 (Atomic Road) north 4.74 miles from Beech Island to U.S. 1/78 (Jefferson Davis Highway) at North Augusta.
06/01/07
Exit ramps depart from U.S. 278/S.C. 215 (Atomic Road) north for S.C. 417 (Augusta Road) east and U.S. 1/78 (Jefferson Davis Highway) south.
06/01/07
S.C. 417 links U.S. 278/S.C. 125 west with U.S. 1/78 north to Aiken via Old Aiken Road (Road 365).
06/01/07
S.C. 417 follows the old alignment of U.S. 1/78 east to Clearwater, Langley, Gloverville and Warrenville.
06/01/07
Photo Credits:
06/01/07, 01/03/08, 09/22/14, 12/31/17, 08/14/21, 09/16/21, 11/21/21, 03/10/22, 09/25/22 by AARoads
Connect with:
Interstate 95
Interstate 520 - Palmetto Parkway
U.S. 1
U.S. 17
U.S. 78
U.S. 301
U.S. 321
U.S. 601
Page Updated 12-02-2022.