U.S. 421 South - Winston-Salem

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U.S. 421
U.S. 421 South

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U.S. 158 East U.S. 421 South

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U.S. 158 North Carolina Highway 150 East U.S. 421 South

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U.S. 421 South North Carolina Highway 150 East

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Connect with:

Interstate 40Interstate 40
Interstate 74Interstate 74
U.S. 52U.S. 52
U.S. 158U.S. 158

Page Updated Friday August 14, 2026.