Researched by Paul Martin, the South Carolina Route Log lists all Interstate, U.S., and State Highways in South Carolina.

The state slogan Smiling Faces. Beautiful Places was incorporated into the new South Carolina license plate in 2000. The Palmetto State redesigned the plate twice since then.

An alternate standard tag design available features the state flag and caption In God We Trust. Vanity tags issued in the state feature an alternate background featuring a mountain and seagrass motif, indicative of the state’s diverse geography.

Five major interstates serve the state. Interstate 20 joins the capital city with Florence and Interstate 95 to the east and Augusta and Atlanta, Georgia to the west. Interstate 26 joins Charleston and the LowCountry with Columbia and the Greenville/Spartanburg area. Interstate 77 provides a link from Columbia northward to Rock Hill and Charlotte, North Carolina. Interstate 85 straddles the Appalachian Mountain Piedmont as a busy freeway linking Atlanta with Charlotte. Interstate 95 travels north-south along the coastal plain, primarily providing through traffic needs between Florida and the Northeast U.S.

Interstate 73 is a planned route from southern North Carolina near Rockingham eastward into the Myrtle Beach and Grand Strand area. Funding delays, environmental concerns due to wetland impacts, and public support have hampered efforts for new corridor. As such, some portions may be built as a toll road to accelerate construction.

Six branch routes serve cities across the Palmetto State. These include Interstate 185, a combination urban spur to Downtown Greenville and tolled loop south of Greenville. Joining I-185 at Greenville is Interstate 385. The lengthy route originates east of Downtown along the Golden Strip Freeway. The freeway circles east and south to Mauldin, where it overtakes U.S. 276 southeast to Simpsonville, Fountain Inn and Clinton where it connects with I-26. Interstate 585 rounds out the Upstate spurs, connecting Business Loop I-85 with Spartanburg alongside U.S. 176 on an older freeway.

Further south, Interstate 126 spurs east from I-26 to Downtown Columbia. The 2009 completed extension of I-520 east to I-20 at North Augusta completed the loop south around Augusta, Georgia. The lone branch route in the LowCountry is Interstate 526. The east-west freeway forms a bypass for U.S. 17 and commuter route from I-26 west and east of Charleston. Efforts continue to complete the loop south and east to the James Island Freeway (South Carolina 30).

Designation Mileage End Points Major Population Centers
20 144.4 (includes 1.8 mile of business spur in Florence) GA border (Savannah River) near North Augusta to US-76 in Florence North Augusta, Aiken, Columbia, Columbia, Camden, Florence
26 221.7 NC border near Landrum to US 17-701 / Meeting St. (Exit 221), downtown Charleston Spartanburg, Clinton, Newberry, Columbia, Orangeburg, Summerville, North Charleston, Charleston
73 TBD NC border north of Bennettsville to S.C. 31 at Myrtle Beach. Marion, Conway, Myrtle Beach
74 TBD NC border near Little River to Myrtle Beach. Myrtle Beach, North Myrtle Beach
77 91.6 I-26 / US 12-176-321 at exit 116 near Cayce to NC Border just south of Charlotte. Columbia, Chester, Rock Hill
85 106.3 GA Border (Tugaloo River) near Fair Play to NC Border near Blacksburg. Anderson, Greenville, Greer, Spartanburg, Gaffney
95 199.2 GA Border (Savannah River) north of Savannah to NC Border north of Dillon. Walterboro, Sumter, Florence, Dillon
126 4.6 (includes 0.5 mile of business spur in Columbia) I-26 exit 108 to US 76 / SC-277 (Bull St.) in downtown Columbia. Columbia
174 24.5 (to be extended to Interstate 74) GA border (Savannah River) to I-20 near North Augusta Myrtle Beach, North Myrtle Beach
185 12.2 (includes 9.6 miles of toll road) I-385, Exit 31 to W. Faris Rd. in SW Greenville Greenville, Mauldin
385 42.4 (includes 0.4 mile of unmarked business spur in downtown Greenville) I-26 exit 51 near Clinton to Academy St. downtown Greenville. Clinton, Laurens, Simpsonville, Mauldin, Greenville
520 7.20 GA border (Savannah River) to I-20 near North Augusta North Augusta
526 22.7 (includes 1.1 mile of business spur in Mt. Pleasant) Corner of US-17 (Savannah Hyw.) & SC-7 (Sam Rittenburg Blvd.) W of Charleston to SC-703 in Mt. Pleasant Charleston, North Charleston, Mt. Pleasant
585 3.1 miles (includes 0.3 mile of business spur multiplexed with US-221 in Spartanburg) Valley Falls Rd. to US-221 in Spartanburg Spartanburg

Much of the original network of U.S. routes within the Palmetto state remains in intact. Some exceptions are the truncation of U.S. 276 due to Interstate 385 and the removal of U.S. 29 Alternate near the Spartanburg vicinity due to Interstate 85. Additional realignments include U.S. 17 with I-95 south from Yemassee, U.S. 15 & 301 with I-95 across Lake Marion, and U.S. 76 along the I-126 spur into Columbia.

SCDOT also assigns U.S. and State Highway spurs. These routes are generally unsigned, and provide connectivity between intersecting or adjacent routes. U.S. 52 Spur extends south to the Charleston historic district as an example.

U.S. 17A northbound at U.S. 15 and South Carolina 64 Business in Walterboro. U.S. 15 begins a six-state run from here. Photo taken by Paul Martin (2001).

Route Mileage Begin End Major Population Centers
1 176 NC Border, 7N Wallace GA Border @ Augusta Cheraw, Camden, Columbia, Lexington, Aiken, 
North Augusta
15 166 NC Border, 2N McColl US 17-A, Walterboro Bennettsville, Hartsville, Sumter, Walterboro
17 229 NC Border, 1N Little River GA Border @ Savannah Myrtle Beach, Georgetown, Charleston
17A 127 US 17, Georgetown US 17, Pocotaligo Moncks Corner, Summerville, Walterboro
21 241 NC Border @ Charlotte Hunting Island State Park Rock Hill, Columbia, Orangeburg, Beaufort
25 139 NC Border, 18N Travelers Rest GA Border @ Augusta Greenville, Greenwood, North Augusta
29 111 NC Border, 7NE Blacksburg GA Border, 15SW Anderson Gaffney, Spartanburg, Greenville, Anderson
52 161 US-17, Charleston NC Border, 10NW Cheraw Charleston, North Charleston, Kingstree, Florence, 
Darlington, Cheraw
76 303 NC Border, 8E Nichols GA Border, 19NW Westminster Marion, Florence, Sumter, Columbia, Newberry,
Laurens, Anderson, Clemson
78 143 US-17, Charleston GA Border @ Augusta Charleston, North Charleston, Summerville, Bamberg, 
Aiken, North Augusta
123 66 BS I-385 (Stone St.), Greenville GA Border, 10W Westminster Greenville, Easley, Clemson, Seneca
176 250 NC Border, 3NW Landrum US-52 S, Goose Creek Spartanburg, Union, Columbia, Goose Creek
178 231 NC Border, 21N Pickens US-78, 3NW Ridgeville Pickens, Anderson, Greenwood, Saluda, Orangeburg
221 124 NC Border, 3N Chesnee GA Border @ Strom Thurmond Dam Spartanburg, Laurens, Greenwood, McCormick
221A 4 NC Border 5 NE Chesnee SC-11 3E Chesnee (none)
276 45 I-385 & Standing Sprs Rd, Mauldin NC Border, Caesars Head S.P. Mauldin, Greenville
278 147 Forest Beach, Hilton Head Island GA Border @ Augusta Hilton Head Is., Ridgeland, Hampton, Allendale,  
North Augusta
301 190 NC Border, South of the Border GA Border, 13W Allendale Dillon, Florence, Manning, Orangeburg, Bamberg,  
Allendale
321 225 NC Border, 4N Clover US-17 S, Hardeeville York, Chester, Winnsboro, Columbia
378 217 US-501/701, Conway GA Border, 8W McCormick Conway, LAke City, Sumter, Columbia, Lexington,  
Saluda, McCormick
401 79 NC Border, 2N McColl US-15, Sumter Bennettsville, Darlington, Sumter
501 77 NC Border, South of the Border US-17, Myrtle Beach Dillon, Marion, Conway, Myrtle Beach
521 172 NC Border, 20N Lancaster US-17/701, Georgetown Lancaster, Camden, Sumter, Manning, Georgetown
601 181 NC Border, 3N Pageland US-321, 23S Hampton Camden, Orangeburg, Bamberg, Hampton
701 122 NC Border, 6N Loris Jct. I-26, Charleston Conway, Georgetown, Charleston

South Carolina state highways are not organized in a north-south or east-west scheme. Route clustering is also not used in the state. Three-digit state highways however act as loops and spurs from their implied parent routes. South Carolina 171 for instance refers to U.S. 17 in its numbering, or can be read as South Carolina 17-1. South Carolina 165 technically reads South Carolina 16-5, as it branches from South Carolina 5. This configuration is not unique to South Carolina, as Washington state also follows the practice.

Several multi state routes join the South Carolina state highway system, including MSR 72 with Georgia, MSR 28 with Georgia and North Carolina, and MSR 121 south to Florida. Freeway construction at Myrtle Beach designated South Carolina 22 as part of the future Interstate 73 corridor and South Carolina 31 along the Carolina Bays Parkway. Carolina Bays Parkway is the potential “eastern” extent for Interstate 74 from coastal North Carolina. S.C. 31 previously was numbered along the Mark Clark Expressway (now I-526) west of Charleston.

S.C. 6 trailblazer at the split of U.S. 17A south and U.S. 52 east at Moncks Corner. South Carolina redesigned the state highway marker in 2007. Debuting then was a design featuring the palmetto tree and crescent moon, symbols from the South Carolina state flag. New signs were grandfathered in throughout the state, initially with the replacement of damaged or missing signs.

The following tables list all routes within the South Carolina State Highway System:

State Highways 2 - 49

Route Approx.
Mileage:		 Begin End
2 4 U.S. 176/321, 2S Cayce U.S. 21/176/321 Cayce
Much in the way Interstate 26 is today, this highway was South Carolina’s “Main Street” in the 1920s and 1930s. Connecting Greenville, Columbia, and Charleston, it was over 200 miles long at one point. It became multiplexed with newer US Federal highway designations (namely U.S. 76, U.S. 176, and U.S. 178) until being phased out everywhere but in the city of Cayce in the 1940s.
3 98 U.S. 321, 1S Swansea U.S. 278, Grays, 14N Ridgeland
4 36 U.S. 301/601, 2W Orangeburg South Carolina 302, Kitchings Mill, 12E Aiken
5 58 South Carolina 18, 6NE Gaffney U.S. 521 S, 7N Lancaster
6 160 U.S. 17A, Moncks Corner U.S. 76, Ballentine, 5NW Irmo
7 6 U.S. 52/78, Rivers Ave. , N. Charleston U.S. 17, Savannah Hyw, Charleston
8 49 U.S. 276, 9S NC Border @ Caesars Head U.S. 25, 5E Pelzer
9 263 South Carolina 65, Ocean Blvd., N. Myrtle Beach NC Border, 19N Spartanburg
10 27 U.S. 25/178 Bus, Greenwood South Carolina 81, 2NW McCormick
11 128 U.S. 29 Gaffney I-85, Exit 1, Fair Play
12 36 U.S. 601, Lugoff, 9W Camden U.S. 1, West Columbia
14 65 I-26, Exit 1, Landrum U.S. 76 Bypass, Laurens
16 16 U.S. 176 (Broad River Rd.), Columbia South Carolina 48 (Assembly St.), Columbia
18 40 NC Border, 9N Gaffney South Carolina 215, 1N Union
19 30 U.S. 25/S.C. 121, 1S Trenton U.S. 278, Savannah River Site, 12S Aiken
20 54 S.C. 72, Abbeville Augusta Road (U.S. 25 Bus.) Greenville
22 28 U.S. 501, 9NW Conway U.S. 17, 6NE Myrtle Beach
South Carolina 22, the “Veteran’s Memorial Highway,” is planned to become part of the Interstate 73 corridor, provided that the section between Candor, North Carolina, and Aynor, South Carolina, is constructed. It was financed from a combination of funds derived from the South Carolina Infrastructure Bank and accommodation taxes collected in the Grand Strand area.
23 44 U.S. 1, 3E Batesburg-Leesville U.S. 221, Modoc, 14S McCormick
24 32 U.S. 76/SC-28 Byp., 1W Anderson U.S. 76/123, 2SE Westminster
27 19 South Carolina 61, Givhans, 7S Ridgeville U.S. 176, 6SE Holly Hill
28 126 U.S. 278, Beech Island, 4S N.Augusta GA Border, 18N Walhalla
South Carolina 28 (Savannah River Scenic Highway) forms a multi state route with Georgia 28 when it criss-crosses the Savannah River into Rabun County and Augusta/Richmond County. It also becomes North Carolina 28 when crossing the Georgia-North Carolina line. Continued from Beech Island to Beaufort until replaced in sections by U.S. 278 and U.S. 21.
30 3 Calhoun St and Lockwood Dr., Charleston South Carolina 171, Folly Road, James Island
South Carolina 30 will become Interstate 526 if the proposed 6.8-mile extension is complete from Folly Road (South Carolina 171) to Savannah Highway (U.S. 17).
31 20 U.S. 501, 6NW Myrtle Beach S.C. 9, 3NW Cherry Grove Section, N. Myrtle Beach
South Carolina 31 was designated along the western seven miles of the Mark Clark Expresssway from 1984-1989 between Interstate 26 and U.S. 17 in Charleston. Upon completion of the eastern leg of the freeway, from I-26 to U.S. 17 north of Mt. Pleasant in 1990, the designation was removed and the entire length renumbered Interstate 526. South Carolina 31 was designated again along the Carolina Bays Parkway. The parkway will eventually extend to connect with U.S. 17 near Pawley’s Island, providing an Interstate-grade freeway bypass of almost the entire Grand Strand area.
33 20 South Carolina 267, Lone Star, 20NE Orangeburg U.S. 301/601, Orangeburg
34 195 U.S. 301/501, Dillon U.S. 25/178 Bus, Greenwood
35 3 I-77, Saxe Gotha Dr., Cayce (aka 12th Street; U.C. as of 1/1/2001, now complete) U.S. 378, Sunset Blvd., W. Columbia
37 16 South Carolina 39, 3 SW Springfield U.S. 278, 2N Barnwell
38 44 NC Border, 13N Bennettsville U.S. 501, 8N Marion
39 89 U.S. 221, 7S Laurens U.S. 278, 5W Williston
41 122 NC Border, 2NE Lake View U.S. 17/701, 5 NE Mt. Pleasant
41A 23 South Carolina 41, 1S Centenary SC 41, Fork, 7SW Lake View
45 77 U.S. 176, Wells, 4NW Holly Hill U.S. 17/701, 1NW McClellanville
46 19 U.S. 278, 2N Bluffton U.S. 278, Hardeeville
47 6 South Carolina 6/267, Ellerbe U.S. 301, 16E Orangeburg
48 30 U.S. 601, Wateree, 14N St. Matthews Bus. Interstate 126/U.S. 76, Elmwood Ave., Columbia
49 67 NC Border @ Lk. Wylie, 9SW Charlotte U.S. 221, 2N Laurens
Route 49 continues an additional 179 miles through NC and 78 miles through VA before ending with a junction of U.S. 360, 7NW Crewe, VA.

State Highways 51-99

Route Approx.
Mileage:		 Begin End
51 69 U.S. 76, Florence U.S. 701, 3N Georgetown
53 12 South Carolina 403, 7SE Lynchburg U.S. 378, 7W Turbeville
55 22 South Carolina 5, 7E Blacksburg U.S. 49, 11NE York
56 68 U.S. 176, 5N Spartanburg South Carolina 39, 2N Chappells
57 27 NC Border, 15N Dillon South Carolina 41, Fork, 6N Mullins
58 15 U.S. 378, Turbeville South Carolina 341, 1SE Lynchburg
59 14 South Carolina 28 Bus., 1st St., Seneca I-85, Exit 2, Fair Play
60 6 U.S. 176, 6NW Columbia South Carolina 6 @ Lake Murray Dam, 5 SW Irmo
61 72 U.S. 78, 5W Branchville U.S. 17, Charleston
63 27 U.S. 17A, 2S Walterboro U.S. 278, Varnville
64 77 U.S. 17 Jacksonboro Savannah River Site, 8W Barnwell
65 10 South Carolina 9 Terminus, Cherry Grove
Section, North Myrtle Beach		 U.S. 17, N.Kings Hyw, Crescent
Beach Section, North Myrtle Beach
South Carolina 65 and the easternmost 1.2 miles of South Carolina 9 from the U.S. 17 interchange at the Intracoastal Waterway bridge was designated as South Carolina 69 from 1972 until around 1980.
66 20 U.S. 176, Whitmire South Carolina 56, 9S Clinton
67 16 U.S. 25/178, 4S Greenwood U.S. 378, 11E McCormick
68 18 U.S. 17A/21, Yemassee U.S. 278, Alameda, 2SE Varnville
70 14 U.S. 301/601, Cordova, 5SW Orangeburg U.S. 278, Barnwell
71 17 South Carolina 72 Abbeville South Carolina 81, 1E Lowndesville
72 124 U.S. 21 Bus, Rock Hill GA Border, 3W Calhoun Falls
South Carolina 72 becomes Georgia 72 at the state line. The western terminus is located at U.S. 29/GA 8 just outside of Athens in Madison County (GA-72 is also a GRIP corridor and a common GA/SC National Highway System (NHS) route).
73 10 U.S. 17, Dunes Section, Myrtle Beach U.S. 17, 2S Myrtle Beach
Also known as Myrtle Beach’s famous “Ocean Boulevard”.
75 7 NC Border, 3W Waxhaw, NC South Carolina 5, Van Wyck, 14E Rock hill
79 9 NC Border, 7NW McColl South Carolina 9, 6NW Bennettsville
80 5.6 U.S. 29, 2W Greer SC 14, 3S Greer
SC 80 was a 3.5 (roughly) mile 4-lane highway called the “J. Verne Smith Parkway”. that was later extended another 2.1 miles to SC 14.
81 94 U.S. 25 Bus., Greenville South Carolina 28, 7NW McCormick
83 6 NC Border, 7SE McColl South Carolina 381, 1NE Clio
86 13 U.S. 25, 11S Greenville South Carolina 8, 5S Easley
88 15 South Carolina 8, 8S Easley South Carolina 187, Pendleton
90 23 U.S. 501 Bus., 2SE Conway U.S. 17, 2SW Little River
92 15 South Carolina 49, 2W Cross Anchor, 13NE Laurens South Carolina 101, Gray Court
93 24 U.S. 123, 2E Easley U.S. 76/123, 2W Clemson
97 95 South Carolina 5, 6SE Blacksburg U.S. 521/601, 2N Camden
99 10 South Carolina 9, 3E Richburg U.S. 21, Great Falls

State Highways 101 - 146

Route Approx.
Mileage:		 Begin End
101 64 South Carolina 11, Cheroke Foothills Parkway U.S. 76, Hickory Tavern, 11W Laurens
102 26 South Carolina 9, Chesterfield U.S. 15 Bus., 2N Hartsville
105 35 I-85, Exit #90, 4W Gaffney South Carolina 49, 8NE Union
107 16 NC Border, 8S Cashiers, NC South Carolina 28, 8N Walhalla
109 14 NC Border, 3N Mt. Croghan South Carolina 145, 8SW Chesterfield
110 9 Jct. U.S. 221A and South Carolina 11, Cherokee Foothills Parkway, 11NW Gaffney U.S. 29, Cowpens
113 14 U.S. 178, Fairview Crossroads, 7W Pelion South Carolina 394, 3W Salley
114 7 South Carolina 18, 4NE Jonesville South Carolina 18, 5N Union
116 3 U.S. 21, 4NW Beaufort Laurel Bay Dr., Laurel Bay
118 11 U.S. 78, 1E Aiken South Carolina 302, 2S Aiken
120 18 U.S. 76/378, 3NW Sumter South Carolina 261, Pinewood
121 129 U.S. 21 Bus., Rock Hill GA Border and U.S. 25, North Augusta
S.C. 121 becomes GA 121 when it crosses into Georgia in Augusta. Ultimately, GA 121 connects to Florida 121. Despite its multi-state route, it never was, nor has it been planned as part of a “U.S. 121.” Instead U.S. 121 is the designation for the Coalfields Expressway corridor in Virginia and West Virginia. (Historical note: U.S. 121 was an original US highway designation from 1926-1933, extending from Lexington, NC to Wytheville, VA. It was superseded with U.S. 52 in 1934).
122 5 I-77, Exit 79, Rock Hill (Dave Lyle Blvd.) South Carolina 5, Rock Hill
124 9 South Carolina 81, Greenville U.S. 123, 6E Easley
125 58 U.S. 25, North Augusta U.S. 301, Allendale
126 5 U.S. 25/SC-121, Belvedere South Carolina 421, Clearwater, 5E N. Augusta
127 4 U.S. 76, 1E Laurens U.S. 221, 2S Laurens
129 6 I-85, Exit #68, 8W Spartanburg U.S. 29, 1N Lyman
130 32 U.S. 76/123, 1N Seneca NC Border @ Whitewater Falls
133 33 South Carolina 11, Cherokee Foothills Parkway U.S. 76/123, Clemson
135 25 South Carolina 8, Pumpkintown, 9N Pickens U.S. 178, 4SE Liberty
137 9 South Carolina 183, 3N Six Mile South Carolina 93, Norris, 3NE Central
145 26 NC Border, 6N Chesterfield U.S. 1, 2N McBee
146 34 South Carolina 56, Cross Anchor, 13N Clinton U.S. 276, Laurens Rd., Greenville

State Highways 150 - 198

Route Approx.
Mileage:		 Begin End
150 34 NC Border, 9N Gaffney South Carolina 56, 13S Spartanburg
151 48 U.S. 601, 1N Pageland South Carolina 34, 7W Darlington
153 7 U.S. 123, 5E Easley I-85 Exit #40, Powdersville, 8SW Greenville
154 17 U.S. 15, Bishopville U.S. 76, Mayesville, 9NE Sumter
157 11 South Carolina 346, 12N Bethune South Carolina 341, 1E Kershaw
160 10 U.S. 521, 5E Fort Mill NC Border, 7SE Charlotte, NC
161 28 NC Border, 6S Kings Mtn., NC U.S. 21, 2NE Rock Hill
162 13 U.S. 17, Rantowles, 11W Charleston South Carolina 174, 23N Edisto Beach
164 2 South Carolina 162, 4W Hollywood South Carolina 174, 22N Edisto Beach
165 28 U.S. 17A, Summerville South Carolina 162, 1S Hollywood
170 36 U.S. 21, 1W Beaufort GA Border, Port Wentworth, GA
170A 6 U.S. 17, 5N Savannah, GA South Carolina 46, 5SE Hardeeville
171 20.5 South Carolina 7/Sam Rittenberg Boulevard in Charleston/West Ashley Arctic Avenue in Folly Beach
South Carolina 171 changes names several times and overlaps with South Carolina 61 for a few miles. From the city of Folly Beach, S.C. 171 begins as Center Street, then changes to Folly Road, then subtly changes again to Folly Road Boulevard. S.C. 171 next briefly changes to Wesley Drive, then turns left onto S.C. 61 (St. Andrews Boulevard). The two state highways soon diverge, with S.C. 171 following Old Towne Road to its terminus at S.C. 7 (Sam Rittenberg Boulevard).2
172 9 U.S. 21, 13N Orangeburg South Carolina 692, 3E North
179 1 U.S. 17, 1N Little River NC Border, 2SW Calabash
181 8 South Carolina 81, 10S Anderson GA Border, 3S Hartwell Dam
182 9 South Carolina 59, Fair Play South Carolina 24, Oakway, 8SE Westminster
183 63 South Carolina 25 Bus., Greenville U.S. 76/123, Westminster
184 33 South Carolina 252, 3NW Ware Shoals GA Border, 7W Iva
185 26 South Carolina 28, 6S Anderson U.S. 178, Hodges
186 15 U.S. 276, Marietta, 5NW Travelers Rest South Carolina 8, 4NE Pickens
187 30 U.S. 76/SC-28, 2S Pendleton South Carolina 184, 6W Iva
188 7 South Carolina 183, 6E Walhalla South Carolina 28, 5NW Seneca
191 23 South Carolina 121, 1S Johnston South Carolina 421, Warrenville, 5W Aiken
193 7 South Carolina 121, 5S Saluda South Carolina 23, Ward, 4E Johnston
194 15 South Carolina 391, 10S Prosperity South Carolina 121, Saluda
198 5 U.S. 29, Blacksburg NC Border, 5N Blacksburg

State Highways 200 - 248

Route Approx.
Mileage:		 Begin End
200 42 NC Border, 9N Lancaster U.S. 321 Bus., Winnsboro
201 13 South Carolina 284, 12S Belton South Carolina 20, 4N Abbeville
202 5 U.S. 176, Pomaria U.S. 76, Little Mountain
203 8 South Carolina 185, 6SE Due West South Carolina 72, Abbeville
207 9 NC Border, 12S Monroe, NC South Carolina 9/US-601, Pageland
210 30 South Carolina 6, Vance U.S. 21, 1N Branchville
211 35 South Carolina 150, Pacolet Mills, 10S Gaffney South Carolina 49, Sharon, 8SW York
212 6 U.S. 21, 2E Williams South Carolina 64, 4S Williams
213 23 U.S. 176, Peak, 4SE Pomaria U.S. 321, Rockton, 3S Winnsboro
215 105 Jct. South Carolina 296, Reidville Rd., Spartanburg U.S. 21, N. Main St., Columbia
216 4 NC Border, 4E Grover, NC Kings Mtn State Park
217 15 South Carolina 61, 7E Smoaks South Carolina 64, Lodge
219 9 U.S. 76, Newberry U.S. 176, 2NW Pomaria
223 7 U.S. 21, 5N Fort Lawn South Carolina 9, Richburg
225 6 South Carolina 72, 1W Greenwood U.S. 25, 4S Greenwood
230 21 U.S. 25/SC-121 N. Augusta South Carolina 23, 9W Edgefield
243 8 South Carolina 24 @ Interstate 85 Exit #11, 14W Anderson South Carolina 59, 2E Fair Play
245 5 South Carolina 391, 3N Batesburg-Leesville U.S. 178, 3S Batesburg-Leesville
246 14 U.S. 178, 12W Saluda U.S. 178, Hodges
247 10 U.S. 25, 5E Pelzer U.S. 76/178, Belton
248 6 South Carolina 34, Ninety-Six U.S. 178, 9SE Greenwood

State Highways 252 - 296

Route Approx.
Mileage:		 Begin End
252 35 U.S. 76, 4W Laurens U.S. 76/178, 6E Anderson
253 20 South Carolina 414, Tigerville South Carolina 124, 5W Greenville
254 11 South Carolina 72, Greenwood U.S. 25 Cokesbury, 8S Ware Shoals
260 12 South Carolina 261, Manning SSR-323 @ Santee Dam
261 116 U.S. 521, 6S Camden U.S. 701, 17S Conway
262 15 U.S. 601, 18E Columbia U.S. 76/378, Garners Fy. Rd., 3E Columbia
263 5 U.S. 76/378, 22E Columbia South Carolina 764, Eastover
265 26 South Carolina 9, Chesterfield U.S. 601, 6N Kershaw
268 5 South Carolina 9/109, Mt. Croghan, 10E Pageland South Carolina 265, 9E Jefferson
269 12 U.S. 321, 4S Winnsboro South Carolina 215, 15N Columbia
274 16 U.S. 21 Bus., Rock Hill NC Border, 10S Gastonia, NC
277 8 U.S. 76 (Corner of Elmwood Ave. & Bull St.), Columbia I-77, 7 NE Columbia
SC DOT purchased right-of-way and planned on an extension connecting S.C. 277 with Interstate 126 in the the 1970’s. Due to neighborhood opposition, this plan was delayed and finally cancelled in the early 1980’s. The right-of-way was returned (“leased for $1”) to the city of Columbia in 2001. SCDOT however still reserved the right to complete the highway on the original right-of-way, should it be needed in the future. This highway was never designated as designated Interstate 277.
280 4 U.S. 21, Burton, 3W Beaufort South Carolina 802, 3W Port Royal
281 3 U.S. 21, Beaufort South Carolina 802, Port Royal
283 18 U.S. 221, Plum Branch, 5S McCormick U.S. 25, 4NW Edgefield
284 19 South Carolina 20/252, 6S Belton South Carolina 81, 9N Calhoun Falls
288 16 U.S. 276, Marietta, 5NW Travelers Rest U.S. 178, 9N Pickens
290 33 U.S. 221, Moore, 10S Spartanburg U.S. 25, 6N Travelers Rest
291 9 U.S. 276/US-25 Bus/SC-253, 2N Greenville (Pleasantburg Dr.) U.S. 25 Bus. @ Interstate 85 Exit #45, 2S Greenville
292 16 South Carolina 9, 5NE Inman South Carolina 290, Duncan
295 17 Bus. Loop Interstate 85 Exit #3, 3NW Spartanburg U.S. 176, 3W Pacolet
296 22 U.S. 176, Spartanburg South Carolina 14, 3E Mauldin

State Highways 300 - 400

Route Approx.
Mileage:		 Begin End
300 11 U.S. 301/321, Ulmer, 9NE Allendale U.S. 278, 4S Barnwell
302 67 U.S. 176/321, W. Columbia South Carolina 125, 5NW Jackson
303 14 U.S. 17A, Walterboro U.S. 17, Green Pond, 10W Jacksonboro
304 5 South Carolina 70, Hilda South Carolina 3, Blackville
308 9 South Carolina 72, Clinton U.S. 221, Ora, 8N Laurens
310 8 South Carolina 6, 1N Vance U.S. 176, 1NW Holly Hill
311 9 South Carolina 6, 2S Cross U.S. 176, 6SE Holly Hill
314 2 U.S. 176, 2NW Holly Hill U.S. 15, 5W Holly Hill
319 13 U.S. 501, Aynor U.S. 701, Homewood, 2N Conway
322 27 U.S. 21 Bus., Rock Hill South Carolina 49 Bullock Cr., 5N Lockhart
324 14 South Carolina 72/121, 6SW Rock Hill South Carolina 5 Bus., 1E York
327 23 I-95 Exit #170, 7NE Florence U.S. 52/301, Effingham, 10S Florence
329 6 South Carolina 18, 3NE Gaffney South Carolina 105, 5SE Gaffney
332 19 U.S. 301/601, 2E Cope South Carolina 4, 3E Springfield
333 3 U.S. 321, Scotia U.S. 601, Furman
336 15 South Carolina 462, 7E Ridgeland U.S. 321, 13N Hardeeville
340 12 South Carolina 34, Darlington South Carolina 403, 3N Timmonsville
341 95 U.S. 521/601, Kershaw South Carolina 41/51, Johnsonville
346 13 South Carolina 341, 1N Bethune South Carolina 903, 13N Bethune
357 16 Near Jct. South Carolina 11 and U.S. 176, Campobello South Carolina 290, 1E Greer
358 3 South Carolina 129, 1N Lyman South Carolina 357, 7NE Greer
362 23 South Carolina 212, Williams U.S. 78, 1E Bamberg
363 13 South Carolina 63, 3N Varnville U.S. 321, Luray, 8W Hampton
375 10 U.S. 521, 1W Greeleyville Jct. South Carolina 377, Gourdin, 15S Kingstree
377 16 South Carolina 261, Kingstree Jct. South Carolina 375, Gourdin, 15S Kingstree
381 20 NC Border, 7NW McColl South Carolina 38, Blenheim, 8S Bennettsville
385 11 South Carolina 79, 11N Bennettsville U.S. 15 Bus., Bennettsville
389 14 South Carolina 39, 1N Perry U.S. 321, Neeses
391 35 U.S. 76, Prosperity South Carolina 39, 10S Batesburg-Leesville
392 4 U.S. 1, 4SW Monetta South Carolina 23/39, Ridge Spring
394 23 U.S. 178, 2W North South Carolina 302, Kitchings Mill, 13E Aiken
395 15 South Carolina 34 Bus., Newberry South Carolina 194, 11NE Saluda

State Highways 400 - 576

Route Approx.
Mileage:		 Begin End
400 12 South Carolina 4, 4W Orangeburg U.S. 321, Norway
402 16 U.S. 17A/US-52, 2NE Moncks Corner South Carolina 41, Huger, 20N Mt. Pleasant
403 36 U.S. 15, 5S Hartsville South Carolina 341, 4NW Lake City
410 18 NC Border, 6N Loris U.S. 701, 10N Conway
412 7 South Carolina 81, Starr, 10S Anderson U.S. 29, 12SE Anderson
413 17 U.S. 76/178, 4SW Belton South Carolina 81, Iva
414 16 South Carolina 14, Gowensville, 11N Greer U.S. 276, Marietta, 4NW Travelers Rest
417 21 U.S. 276, Mauldin South Carolina 296, 7W Spartanburg
418 26 U.S. 221, 1NW Woodruff U.S. 25, 5E Pelzer
419 6 SSR 25, Ft. Motte, 8NE St. Matthews SC 267, 10E St. Matthews
420 5 U.S. 25, Shoals Jct., 6N Hodges South Carolina 252/US-25 Bus., Ware Shoals
421 14 South Carolina 118, 4W Aiken U.S. 278, 1S North Augusta
430 12 South Carolina 23, 2E Edgefield U.S. 378, 10W Saluda
441 18 U.S. 15, Manville, 8SW Bishopville U.S. 76/378, 10W Sumter
453 14 South Carolina 6, Eutawville U.S. 178, Harleyville
462 40 U.S. 278, 12E Hardeeville U.S. 321, Robertville, 19NW Ridgeland
512 24 South Carolina 513, 8S Hemingway U.S. 52, Cades, 7S Lake City
513 10 South Carolina 41, 9S Hemingway South Carolina 261, 10E Hemingway
517 4 U.S. 17, Mt. Pleasant South Carolina 703, Isle of Palms
522 30 South Carolina 97, Liberty Hill NC Border, 13NE Lancaster
527 71 South Carolina 341, Wisacky, 6SE Bishopville South Carolina 41, 4N Andrews
541 10 U.S. 52, Coward, 7N Lake City South Carolina 341, Olanta, 7NE Turbeville
544 16 U.S. 501 Bus., 2SE Conway U.S. 17, 1N Surfside Beach
552 7 South Carolina 49/274, L. Wylie, 12SE Gastonia, NC South Carolina 55, 2E Clover
555 12 U.S. 21, 3S Blythewood U.S. 76, Gervais St., Columbia
576 3 U.S. 501 Bus./SC-41A, 2SE Marion U.S. 76, 1W Marion

State Highways 602 - 917

Route Approx.
Mileage:		 Begin End
602 13 U.S. 1, West Columbia South Carolina 6, Red Bank, 6S Lexington
641 22 U.S. 301, 2NE Allendale South Carolina 64, Ashton, 21W Walterboro
642 20 U.S. 52/78, Rivers Ave., N. Charleston U.S. 17A, 7SW Summerville
651 8 U.S. 61, 7E Canadys U.S. 17A, 1W Cottageville
652 11 U.S. 278, 4N Ridgeland U.S. 601, Pineland, 20S Hampton
692 9 U.S. 178, 3E North U.S. 321, Swansea
700 21 South Carolina 171, Folly Road, James Island Rockville, 25SW Charleston
702 19 South Carolina 39, 4NW Saluda South Carolina 246, 3N Ninety-Six
703 13 U.S. 17/701, Mt. Pleasant N end of Isle of Palms
707 15 U.S. 17, 3W Myrtle Beach U.S. 17 Bus., Murrells Inlet
742 4 NC Border, 6N Chesterfield South Carolina 145, 2N Chesterfield
760 2 U.S. 76/378, Garners Fy. Rd., Columbia Fort Jackson
763 14 U.S. 378, 2E Sumter South Carolina 261, Wedgefield, 9W Sumter
764 9 U.S. 601, 2E Eastover U.S. 76/378, 15E Columbia
768 5 U.S. 76/378, Garners Fy. Rd., 6E Columbia South Carolina 48, Bluff Rd., 4SE Columbia
769 10 U.S. 76/378, Horrell Hill, 12E Columbia South Carolina 48, Gadsden, 18E Columbia
773 5 U.S. 176, Pomaria U.S. 76, 3E Prosperity
781 4 U.S. 78, 3W Williston U.S. 278, 7W Williston
802 17 Wilkins, Lady’s Island, 10E Beaufort South Carolina 170, 7W Beaufort
823 11 South Carolina 81, Mt. Carmel South Carolina 72, 4 SW Abbeville
901 35 South Carolina 5, 2W Rock Hill South Carolina 200, 10N Winnsboro
903 25 U.S. 521 Byp., Lancaster South Carolina 151, 6S Jefferson
905 24 NC Border, 4NE Longs U.S. 501 Bus., Conway
908 8 U.S. 378, Britton’s Neck, 17W Conway U.S. 41, 4S Centenary
909 12 U.S. 321, Lowrys, 8N Chester South Carolina 9, 6W Richburg
912 8 South Carolina 9, 7NW Bennettsville U.S. 15/401, 7NE Society Hill
914 1.7 South Carolina 200, 1.9W Lancaster South Carolina 9 Business, 2.8SW Lancaster
917 41 South Carolina 38, 5W Latta South Carolina 9 Bus., 6W Loris