Researched by Paul Martin, the South Carolina Route Log lists all Interstate, U.S., and State Highways in South Carolina.
The state slogan Smiling Faces. Beautiful Places was incorporated into the new South Carolina license plate in 2000. The Palmetto State redesigned the plate twice since then.
An alternate standard tag design available features the state flag and caption In God We Trust. Vanity tags issued in the state feature an alternate background featuring a mountain and seagrass motif, indicative of the state’s diverse geography.
Five major interstates serve the state. Interstate 20 joins the capital city with Florence and Interstate 95 to the east and Augusta and Atlanta, Georgia to the west. Interstate 26 joins Charleston and the LowCountry with Columbia and the Greenville/Spartanburg area. Interstate 77 provides a link from Columbia northward to Rock Hill and Charlotte, North Carolina. Interstate 85 straddles the Appalachian Mountain Piedmont as a busy freeway linking Atlanta with Charlotte. Interstate 95 travels north-south along the coastal plain, primarily providing through traffic needs between Florida and the Northeast U.S.
Interstate 73 is a planned route from southern North Carolina near Rockingham eastward into the Myrtle Beach and Grand Strand area. Funding delays, environmental concerns due to wetland impacts, and public support have hampered efforts for new corridor. As such, some portions may be built as a toll road to accelerate construction.
Six branch routes serve cities across the Palmetto State. These include Interstate 185, a combination urban spur to Downtown Greenville and tolled loop south of Greenville. Joining I-185 at Greenville is Interstate 385. The lengthy route originates east of Downtown along the Golden Strip Freeway. The freeway circles east and south to Mauldin, where it overtakes U.S. 276 southeast to Simpsonville, Fountain Inn and Clinton where it connects with I-26. Interstate 585 rounds out the Upstate spurs, connecting Business Loop I-85 with Spartanburg alongside U.S. 176 on an older freeway.
Further south, Interstate 126 spurs east from I-26 to Downtown Columbia. The 2009 completed extension of I-520 east to I-20 at North Augusta completed the loop south around Augusta, Georgia. The lone branch route in the LowCountry is Interstate 526. The east-west freeway forms a bypass for U.S. 17 and commuter route from I-26 west and east of Charleston. Efforts continue to complete the loop south and east to the James Island Freeway (South Carolina 30).
| Designation | Mileage | End Points | Major Population Centers |
|---|---|---|---|
| 20 | 144.4 (includes 1.8 mile of business spur in Florence) | GA border (Savannah River) near North Augusta to US-76 in Florence | North Augusta, Aiken, Columbia, Columbia, Camden, Florence |
| 26 | 221.7 | NC border near Landrum to US 17-701 / Meeting St. (Exit 221), downtown Charleston | Spartanburg, Clinton, Newberry, Columbia, Orangeburg, Summerville, North Charleston, Charleston |
| 73 | TBD | NC border north of Bennettsville to S.C. 31 at Myrtle Beach. | Marion, Conway, Myrtle Beach |
| 74 | TBD | NC border near Little River to Myrtle Beach. | Myrtle Beach, North Myrtle Beach |
| 77 | 91.6 | I-26 / US 12-176-321 at exit 116 near Cayce to NC Border just south of Charlotte. | Columbia, Chester, Rock Hill |
| 85 | 106.3 | GA Border (Tugaloo River) near Fair Play to NC Border near Blacksburg. | Anderson, Greenville, Greer, Spartanburg, Gaffney |
| 95 | 199.2 | GA Border (Savannah River) north of Savannah to NC Border north of Dillon. | Walterboro, Sumter, Florence, Dillon |
| 126 | 4.6 (includes 0.5 mile of business spur in Columbia) | I-26 exit 108 to US 76 / SC-277 (Bull St.) in downtown Columbia. | Columbia |
| 24.5 (to be extended to Interstate 74) | GA border (Savannah River) to I-20 near North Augusta | Myrtle Beach, North Myrtle Beach | |
| 185 | 12.2 (includes 9.6 miles of toll road) | I-385, Exit 31 to W. Faris Rd. in SW Greenville | Greenville, Mauldin |
| 385 | 42.4 (includes 0.4 mile of unmarked business spur in downtown Greenville) | I-26 exit 51 near Clinton to Academy St. downtown Greenville. | Clinton, Laurens, Simpsonville, Mauldin, Greenville |
| 520 | 7.20 | GA border (Savannah River) to I-20 near North Augusta | North Augusta |
| 526 | 22.7 (includes 1.1 mile of business spur in Mt. Pleasant) | Corner of US-17 (Savannah Hyw.) & SC-7 (Sam Rittenburg Blvd.) W of Charleston to SC-703 in Mt. Pleasant | Charleston, North Charleston, Mt. Pleasant |
| 585 | 3.1 miles (includes 0.3 mile of business spur multiplexed with US-221 in Spartanburg) | Valley Falls Rd. to US-221 in Spartanburg | Spartanburg |
Much of the original network of U.S. routes within the Palmetto state remains in intact. Some exceptions are the truncation of U.S. 276 due to Interstate 385 and the removal of U.S. 29 Alternate near the Spartanburg vicinity due to Interstate 85. Additional realignments include U.S. 17 with I-95 south from Yemassee, U.S. 15 & 301 with I-95 across Lake Marion, and U.S. 76 along the I-126 spur into Columbia.
SCDOT also assigns U.S. and State Highway spurs. These routes are generally unsigned, and provide connectivity between intersecting or adjacent routes. U.S. 52 Spur extends south to the Charleston historic district as an example.
U.S. 17A northbound at U.S. 15 and South Carolina 64 Business in Walterboro. U.S. 15 begins a six-state run from here. Photo taken by Paul Martin (2001).
| Route | Mileage | Begin | End | Major Population Centers |
|---|---|---|---|---|
| 1 | 176 | NC Border, 7N Wallace | GA Border @ Augusta | Cheraw, Camden, Columbia, Lexington, Aiken, North Augusta |
| 15 | 166 | NC Border, 2N McColl | US 17-A, Walterboro | Bennettsville, Hartsville, Sumter, Walterboro |
| 17 | 229 | NC Border, 1N Little River | GA Border @ Savannah | Myrtle Beach, Georgetown, Charleston |
| 17A | 127 | US 17, Georgetown | US 17, Pocotaligo | Moncks Corner, Summerville, Walterboro |
| 21 | 241 | NC Border @ Charlotte | Hunting Island State Park | Rock Hill, Columbia, Orangeburg, Beaufort |
| 25 | 139 | NC Border, 18N Travelers Rest | GA Border @ Augusta | Greenville, Greenwood, North Augusta |
| 29 | 111 | NC Border, 7NE Blacksburg | GA Border, 15SW Anderson | Gaffney, Spartanburg, Greenville, Anderson |
| 52 | 161 | US-17, Charleston | NC Border, 10NW Cheraw | Charleston, North Charleston, Kingstree, Florence, Darlington, Cheraw |
| 76 | 303 | NC Border, 8E Nichols | GA Border, 19NW Westminster | Marion, Florence, Sumter, Columbia, Newberry, Laurens, Anderson, Clemson |
| 78 | 143 | US-17, Charleston | GA Border @ Augusta | Charleston, North Charleston, Summerville, Bamberg, Aiken, North Augusta |
| 123 | 66 | BS I-385 (Stone St.), Greenville | GA Border, 10W Westminster | Greenville, Easley, Clemson, Seneca |
| 176 | 250 | NC Border, 3NW Landrum | US-52 S, Goose Creek | Spartanburg, Union, Columbia, Goose Creek |
| 178 | 231 | NC Border, 21N Pickens | US-78, 3NW Ridgeville | Pickens, Anderson, Greenwood, Saluda, Orangeburg |
| 221 | 124 | NC Border, 3N Chesnee | GA Border @ Strom Thurmond Dam | Spartanburg, Laurens, Greenwood, McCormick |
| 221A | 4 | NC Border 5 NE Chesnee | SC-11 3E Chesnee | (none) |
| 276 | 45 | I-385 & Standing Sprs Rd, Mauldin | NC Border, Caesars Head S.P. | Mauldin, Greenville |
| 278 | 147 | Forest Beach, Hilton Head Island | GA Border @ Augusta | Hilton Head Is., Ridgeland, Hampton, Allendale, North Augusta |
| 301 | 190 | NC Border, South of the Border | GA Border, 13W Allendale | Dillon, Florence, Manning, Orangeburg, Bamberg, Allendale |
| 321 | 225 | NC Border, 4N Clover | US-17 S, Hardeeville | York, Chester, Winnsboro, Columbia |
| 378 | 217 | US-501/701, Conway | GA Border, 8W McCormick | Conway, LAke City, Sumter, Columbia, Lexington, Saluda, McCormick |
| 401 | 79 | NC Border, 2N McColl | US-15, Sumter | Bennettsville, Darlington, Sumter |
| 501 | 77 | NC Border, South of the Border | US-17, Myrtle Beach | Dillon, Marion, Conway, Myrtle Beach |
| 521 | 172 | NC Border, 20N Lancaster | US-17/701, Georgetown | Lancaster, Camden, Sumter, Manning, Georgetown |
| 601 | 181 | NC Border, 3N Pageland | US-321, 23S Hampton | Camden, Orangeburg, Bamberg, Hampton |
| 701 | 122 | NC Border, 6N Loris | Jct. I-26, Charleston | Conway, Georgetown, Charleston |
South Carolina state highways are not organized in a north-south or east-west scheme. Route clustering is also not used in the state. Three-digit state highways however act as loops and spurs from their implied parent routes. South Carolina 171 for instance refers to U.S. 17 in its numbering, or can be read as South Carolina 17-1. South Carolina 165 technically reads South Carolina 16-5, as it branches from South Carolina 5. This configuration is not unique to South Carolina, as Washington state also follows the practice.
Several multi state routes join the South Carolina state highway system, including MSR 72 with Georgia, MSR 28 with Georgia and North Carolina, and MSR 121 south to Florida. Freeway construction at Myrtle Beach designated South Carolina 22 as part of the future Interstate 73 corridor and South Carolina 31 along the Carolina Bays Parkway. Carolina Bays Parkway is the potential “eastern” extent for Interstate 74 from coastal North Carolina. S.C. 31 previously was numbered along the Mark Clark Expressway (now I-526) west of Charleston.
S.C. 6 trailblazer at the split of U.S. 17A south and U.S. 52 east at Moncks Corner. South Carolina redesigned the state highway marker in 2007. Debuting then was a design featuring the palmetto tree and crescent moon, symbols from the South Carolina state flag. New signs were grandfathered in throughout the state, initially with the replacement of damaged or missing signs.
The following tables list all routes within the South Carolina State Highway System:
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 2 | 4 | U.S. 176/321, 2S Cayce | U.S. 21/176/321 Cayce |
| Much in the way Interstate 26 is today, this highway was South Carolina’s “Main Street” in the 1920s and 1930s. Connecting Greenville, Columbia, and Charleston, it was over 200 miles long at one point. It became multiplexed with newer US Federal highway designations (namely U.S. 76, U.S. 176, and U.S. 178) until being phased out everywhere but in the city of Cayce in the 1940s. | |||
| 3 | 98 | U.S. 321, 1S Swansea | U.S. 278, Grays, 14N Ridgeland |
| 4 | 36 | U.S. 301/601, 2W Orangeburg | South Carolina 302, Kitchings Mill, 12E Aiken |
| 5 | 58 | South Carolina 18, 6NE Gaffney | U.S. 521 S, 7N Lancaster |
| 6 | 160 | U.S. 17A, Moncks Corner | U.S. 76, Ballentine, 5NW Irmo |
| 7 | 6 | U.S. 52/78, Rivers Ave. , N. Charleston | U.S. 17, Savannah Hyw, Charleston |
| 8 | 49 | U.S. 276, 9S NC Border @ Caesars Head | U.S. 25, 5E Pelzer |
| 9 | 263 | South Carolina 65, Ocean Blvd., N. Myrtle Beach | NC Border, 19N Spartanburg |
| 10 | 27 | U.S. 25/178 Bus, Greenwood | South Carolina 81, 2NW McCormick |
| 11 | 128 | U.S. 29 Gaffney | I-85, Exit 1, Fair Play |
| 12 | 36 | U.S. 601, Lugoff, 9W Camden | U.S. 1, West Columbia |
| 14 | 65 | I-26, Exit 1, Landrum | U.S. 76 Bypass, Laurens |
| 16 | 16 | U.S. 176 (Broad River Rd.), Columbia | South Carolina 48 (Assembly St.), Columbia |
| 18 | 40 | NC Border, 9N Gaffney | South Carolina 215, 1N Union |
| 19 | 30 | U.S. 25/S.C. 121, 1S Trenton | U.S. 278, Savannah River Site, 12S Aiken |
| 20 | 54 | S.C. 72, Abbeville | Augusta Road (U.S. 25 Bus.) Greenville |
| 22 | 28 | U.S. 501, 9NW Conway | U.S. 17, 6NE Myrtle Beach |
| South Carolina 22, the “Veteran’s Memorial Highway,” is planned to become part of the Interstate 73 corridor, provided that the section between Candor, North Carolina, and Aynor, South Carolina, is constructed. It was financed from a combination of funds derived from the South Carolina Infrastructure Bank and accommodation taxes collected in the Grand Strand area. | |||
| 23 | 44 | U.S. 1, 3E Batesburg-Leesville | U.S. 221, Modoc, 14S McCormick |
| 24 | 32 | U.S. 76/SC-28 Byp., 1W Anderson | U.S. 76/123, 2SE Westminster |
| 27 | 19 | South Carolina 61, Givhans, 7S Ridgeville | U.S. 176, 6SE Holly Hill |
| 28 | 126 | U.S. 278, Beech Island, 4S N.Augusta | GA Border, 18N Walhalla |
| South Carolina 28 (Savannah River Scenic Highway) forms a multi state route with Georgia 28 when it criss-crosses the Savannah River into Rabun County and Augusta/Richmond County. It also becomes North Carolina 28 when crossing the Georgia-North Carolina line. Continued from Beech Island to Beaufort until replaced in sections by U.S. 278 and U.S. 21. | |||
| 30 | 3 | Calhoun St and Lockwood Dr., Charleston | South Carolina 171, Folly Road, James Island |
| South Carolina 30 will become Interstate 526 if the proposed 6.8-mile extension is complete from Folly Road (South Carolina 171) to Savannah Highway (U.S. 17). | |||
| 31 | 20 | U.S. 501, 6NW Myrtle Beach | S.C. 9, 3NW Cherry Grove Section, N. Myrtle Beach |
| South Carolina 31 was designated along the western seven miles of the Mark Clark Expresssway from 1984-1989 between Interstate 26 and U.S. 17 in Charleston. Upon completion of the eastern leg of the freeway, from I-26 to U.S. 17 north of Mt. Pleasant in 1990, the designation was removed and the entire length renumbered Interstate 526. South Carolina 31 was designated again along the Carolina Bays Parkway. The parkway will eventually extend to connect with U.S. 17 near Pawley’s Island, providing an Interstate-grade freeway bypass of almost the entire Grand Strand area. | |||
| 33 | 20 | South Carolina 267, Lone Star, 20NE Orangeburg | U.S. 301/601, Orangeburg |
| 34 | 195 | U.S. 301/501, Dillon | U.S. 25/178 Bus, Greenwood |
| 35 | 3 | I-77, Saxe Gotha Dr., Cayce (aka 12th Street; U.C. as of 1/1/2001, now complete) | U.S. 378, Sunset Blvd., W. Columbia |
| 37 | 16 | South Carolina 39, 3 SW Springfield | U.S. 278, 2N Barnwell |
| 38 | 44 | NC Border, 13N Bennettsville | U.S. 501, 8N Marion |
| 39 | 89 | U.S. 221, 7S Laurens | U.S. 278, 5W Williston |
| 41 | 122 | NC Border, 2NE Lake View | U.S. 17/701, 5 NE Mt. Pleasant |
| 41A | 23 | South Carolina 41, 1S Centenary | SC 41, Fork, 7SW Lake View |
| 45 | 77 | U.S. 176, Wells, 4NW Holly Hill | U.S. 17/701, 1NW McClellanville |
| 46 | 19 | U.S. 278, 2N Bluffton | U.S. 278, Hardeeville |
| 47 | 6 | South Carolina 6/267, Ellerbe | U.S. 301, 16E Orangeburg |
| 48 | 30 | U.S. 601, Wateree, 14N St. Matthews | Bus. Interstate 126/U.S. 76, Elmwood Ave., Columbia |
| 49 | 67 | NC Border @ Lk. Wylie, 9SW Charlotte | U.S. 221, 2N Laurens |
| Route 49 continues an additional 179 miles through NC and 78 miles through VA before ending with a junction of U.S. 360, 7NW Crewe, VA. | |||
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 51 | 69 | U.S. 76, Florence | U.S. 701, 3N Georgetown |
| 53 | 12 | South Carolina 403, 7SE Lynchburg | U.S. 378, 7W Turbeville |
| 55 | 22 | South Carolina 5, 7E Blacksburg | U.S. 49, 11NE York |
| 56 | 68 | U.S. 176, 5N Spartanburg | South Carolina 39, 2N Chappells |
| 57 | 27 | NC Border, 15N Dillon | South Carolina 41, Fork, 6N Mullins |
| 58 | 15 | U.S. 378, Turbeville | South Carolina 341, 1SE Lynchburg |
| 59 | 14 | South Carolina 28 Bus., 1st St., Seneca | I-85, Exit 2, Fair Play |
| 60 | 6 | U.S. 176, 6NW Columbia | South Carolina 6 @ Lake Murray Dam, 5 SW Irmo |
| 61 | 72 | U.S. 78, 5W Branchville | U.S. 17, Charleston |
| 63 | 27 | U.S. 17A, 2S Walterboro | U.S. 278, Varnville |
| 64 | 77 | U.S. 17 Jacksonboro | Savannah River Site, 8W Barnwell |
| 65 | 10 | South Carolina 9 Terminus, Cherry Grove Section, North Myrtle Beach |
U.S. 17, N.Kings Hyw, Crescent Beach Section, North Myrtle Beach |
| South Carolina 65 and the easternmost 1.2 miles of South Carolina 9 from the U.S. 17 interchange at the Intracoastal Waterway bridge was designated as South Carolina 69 from 1972 until around 1980. | |||
| 66 | 20 | U.S. 176, Whitmire | South Carolina 56, 9S Clinton |
| 67 | 16 | U.S. 25/178, 4S Greenwood | U.S. 378, 11E McCormick |
| 68 | 18 | U.S. 17A/21, Yemassee | U.S. 278, Alameda, 2SE Varnville |
| 70 | 14 | U.S. 301/601, Cordova, 5SW Orangeburg | U.S. 278, Barnwell |
| 71 | 17 | South Carolina 72 Abbeville | South Carolina 81, 1E Lowndesville |
| 72 | 124 | U.S. 21 Bus, Rock Hill | GA Border, 3W Calhoun Falls |
| South Carolina 72 becomes Georgia 72 at the state line. The western terminus is located at U.S. 29/GA 8 just outside of Athens in Madison County (GA-72 is also a GRIP corridor and a common GA/SC National Highway System (NHS) route). | |||
| 73 | 10 | U.S. 17, Dunes Section, Myrtle Beach | U.S. 17, 2S Myrtle Beach |
| Also known as Myrtle Beach’s famous “Ocean Boulevard”. | |||
| 75 | 7 | NC Border, 3W Waxhaw, NC | South Carolina 5, Van Wyck, 14E Rock hill |
| 79 | 9 | NC Border, 7NW McColl | South Carolina 9, 6NW Bennettsville |
| 80 | 5.6 | U.S. 29, 2W Greer | SC 14, 3S Greer |
| SC 80 was a 3.5 (roughly) mile 4-lane highway called the “J. Verne Smith Parkway”. that was later extended another 2.1 miles to SC 14. | |||
| 81 | 94 | U.S. 25 Bus., Greenville | South Carolina 28, 7NW McCormick |
| 83 | 6 | NC Border, 7SE McColl | South Carolina 381, 1NE Clio |
| 86 | 13 | U.S. 25, 11S Greenville | South Carolina 8, 5S Easley |
| 88 | 15 | South Carolina 8, 8S Easley | South Carolina 187, Pendleton |
| 90 | 23 | U.S. 501 Bus., 2SE Conway | U.S. 17, 2SW Little River |
| 92 | 15 | South Carolina 49, 2W Cross Anchor, 13NE Laurens | South Carolina 101, Gray Court |
| 93 | 24 | U.S. 123, 2E Easley | U.S. 76/123, 2W Clemson |
| 97 | 95 | South Carolina 5, 6SE Blacksburg | U.S. 521/601, 2N Camden |
| 99 | 10 | South Carolina 9, 3E Richburg | U.S. 21, Great Falls |
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 101 | 64 | South Carolina 11, Cheroke Foothills Parkway | U.S. 76, Hickory Tavern, 11W Laurens |
| 102 | 26 | South Carolina 9, Chesterfield | U.S. 15 Bus., 2N Hartsville |
| 105 | 35 | I-85, Exit #90, 4W Gaffney | South Carolina 49, 8NE Union |
| 107 | 16 | NC Border, 8S Cashiers, NC | South Carolina 28, 8N Walhalla |
| 109 | 14 | NC Border, 3N Mt. Croghan | South Carolina 145, 8SW Chesterfield |
| 110 | 9 | Jct. U.S. 221A and South Carolina 11, Cherokee Foothills Parkway, 11NW Gaffney | U.S. 29, Cowpens |
| 113 | 14 | U.S. 178, Fairview Crossroads, 7W Pelion | South Carolina 394, 3W Salley |
| 114 | 7 | South Carolina 18, 4NE Jonesville | South Carolina 18, 5N Union |
| 116 | 3 | U.S. 21, 4NW Beaufort | Laurel Bay Dr., Laurel Bay |
| 118 | 11 | U.S. 78, 1E Aiken | South Carolina 302, 2S Aiken |
| 120 | 18 | U.S. 76/378, 3NW Sumter | South Carolina 261, Pinewood |
| 121 | 129 | U.S. 21 Bus., Rock Hill | GA Border and U.S. 25, North Augusta |
| S.C. 121 becomes GA 121 when it crosses into Georgia in Augusta. Ultimately, GA 121 connects to Florida 121. Despite its multi-state route, it never was, nor has it been planned as part of a “U.S. 121.” Instead U.S. 121 is the designation for the Coalfields Expressway corridor in Virginia and West Virginia. (Historical note: U.S. 121 was an original US highway designation from 1926-1933, extending from Lexington, NC to Wytheville, VA. It was superseded with U.S. 52 in 1934). | |||
| 122 | 5 | I-77, Exit 79, Rock Hill (Dave Lyle Blvd.) | South Carolina 5, Rock Hill |
| 124 | 9 | South Carolina 81, Greenville | U.S. 123, 6E Easley |
| 125 | 58 | U.S. 25, North Augusta | U.S. 301, Allendale |
| 126 | 5 | U.S. 25/SC-121, Belvedere | South Carolina 421, Clearwater, 5E N. Augusta |
| 127 | 4 | U.S. 76, 1E Laurens | U.S. 221, 2S Laurens |
| 129 | 6 | I-85, Exit #68, 8W Spartanburg | U.S. 29, 1N Lyman |
| 130 | 32 | U.S. 76/123, 1N Seneca | NC Border @ Whitewater Falls |
| 133 | 33 | South Carolina 11, Cherokee Foothills Parkway | U.S. 76/123, Clemson |
| 135 | 25 | South Carolina 8, Pumpkintown, 9N Pickens | U.S. 178, 4SE Liberty |
| 137 | 9 | South Carolina 183, 3N Six Mile | South Carolina 93, Norris, 3NE Central |
| 145 | 26 | NC Border, 6N Chesterfield | U.S. 1, 2N McBee |
| 146 | 34 | South Carolina 56, Cross Anchor, 13N Clinton | U.S. 276, Laurens Rd., Greenville |
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 150 | 34 | NC Border, 9N Gaffney | South Carolina 56, 13S Spartanburg |
| 151 | 48 | U.S. 601, 1N Pageland | South Carolina 34, 7W Darlington |
| 153 | 7 | U.S. 123, 5E Easley | I-85 Exit #40, Powdersville, 8SW Greenville |
| 154 | 17 | U.S. 15, Bishopville | U.S. 76, Mayesville, 9NE Sumter |
| 157 | 11 | South Carolina 346, 12N Bethune | South Carolina 341, 1E Kershaw |
| 160 | 10 | U.S. 521, 5E Fort Mill | NC Border, 7SE Charlotte, NC |
| 161 | 28 | NC Border, 6S Kings Mtn., NC | U.S. 21, 2NE Rock Hill |
| 162 | 13 | U.S. 17, Rantowles, 11W Charleston | South Carolina 174, 23N Edisto Beach |
| 164 | 2 | South Carolina 162, 4W Hollywood | South Carolina 174, 22N Edisto Beach |
| 165 | 28 | U.S. 17A, Summerville | South Carolina 162, 1S Hollywood |
| 170 | 36 | U.S. 21, 1W Beaufort | GA Border, Port Wentworth, GA |
| 170A | 6 | U.S. 17, 5N Savannah, GA | South Carolina 46, 5SE Hardeeville |
| 171 | 20.5 | South Carolina 7/Sam Rittenberg Boulevard in Charleston/West Ashley | Arctic Avenue in Folly Beach |
| South Carolina 171 changes names several times and overlaps with South Carolina 61 for a few miles. From the city of Folly Beach, S.C. 171 begins as Center Street, then changes to Folly Road, then subtly changes again to Folly Road Boulevard. S.C. 171 next briefly changes to Wesley Drive, then turns left onto S.C. 61 (St. Andrews Boulevard). The two state highways soon diverge, with S.C. 171 following Old Towne Road to its terminus at S.C. 7 (Sam Rittenberg Boulevard).2 | |||
| 172 | 9 | U.S. 21, 13N Orangeburg | South Carolina 692, 3E North |
| 179 | 1 | U.S. 17, 1N Little River | NC Border, 2SW Calabash |
| 181 | 8 | South Carolina 81, 10S Anderson | GA Border, 3S Hartwell Dam |
| 182 | 9 | South Carolina 59, Fair Play | South Carolina 24, Oakway, 8SE Westminster |
| 183 | 63 | South Carolina 25 Bus., Greenville | U.S. 76/123, Westminster |
| 184 | 33 | South Carolina 252, 3NW Ware Shoals | GA Border, 7W Iva |
| 185 | 26 | South Carolina 28, 6S Anderson | U.S. 178, Hodges |
| 186 | 15 | U.S. 276, Marietta, 5NW Travelers Rest | South Carolina 8, 4NE Pickens |
| 187 | 30 | U.S. 76/SC-28, 2S Pendleton | South Carolina 184, 6W Iva |
| 188 | 7 | South Carolina 183, 6E Walhalla | South Carolina 28, 5NW Seneca |
| 191 | 23 | South Carolina 121, 1S Johnston | South Carolina 421, Warrenville, 5W Aiken |
| 193 | 7 | South Carolina 121, 5S Saluda | South Carolina 23, Ward, 4E Johnston |
| 194 | 15 | South Carolina 391, 10S Prosperity | South Carolina 121, Saluda |
| 198 | 5 | U.S. 29, Blacksburg | NC Border, 5N Blacksburg |
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 200 | 42 | NC Border, 9N Lancaster | U.S. 321 Bus., Winnsboro |
| 201 | 13 | South Carolina 284, 12S Belton | South Carolina 20, 4N Abbeville |
| 202 | 5 | U.S. 176, Pomaria | U.S. 76, Little Mountain |
| 203 | 8 | South Carolina 185, 6SE Due West | South Carolina 72, Abbeville |
| 207 | 9 | NC Border, 12S Monroe, NC | South Carolina 9/US-601, Pageland |
| 210 | 30 | South Carolina 6, Vance | U.S. 21, 1N Branchville |
| 211 | 35 | South Carolina 150, Pacolet Mills, 10S Gaffney | South Carolina 49, Sharon, 8SW York |
| 212 | 6 | U.S. 21, 2E Williams | South Carolina 64, 4S Williams |
| 213 | 23 | U.S. 176, Peak, 4SE Pomaria | U.S. 321, Rockton, 3S Winnsboro |
| 215 | 105 | Jct. South Carolina 296, Reidville Rd., Spartanburg | U.S. 21, N. Main St., Columbia |
| 216 | 4 | NC Border, 4E Grover, NC | Kings Mtn State Park |
| 217 | 15 | South Carolina 61, 7E Smoaks | South Carolina 64, Lodge |
| 219 | 9 | U.S. 76, Newberry | U.S. 176, 2NW Pomaria |
| 223 | 7 | U.S. 21, 5N Fort Lawn | South Carolina 9, Richburg |
| 225 | 6 | South Carolina 72, 1W Greenwood | U.S. 25, 4S Greenwood |
| 230 | 21 | U.S. 25/SC-121 N. Augusta | South Carolina 23, 9W Edgefield |
| 243 | 8 | South Carolina 24 @ Interstate 85 Exit #11, 14W Anderson | South Carolina 59, 2E Fair Play |
| 245 | 5 | South Carolina 391, 3N Batesburg-Leesville | U.S. 178, 3S Batesburg-Leesville |
| 246 | 14 | U.S. 178, 12W Saluda | U.S. 178, Hodges |
| 247 | 10 | U.S. 25, 5E Pelzer | U.S. 76/178, Belton |
| 248 | 6 | South Carolina 34, Ninety-Six | U.S. 178, 9SE Greenwood |
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 252 | 35 | U.S. 76, 4W Laurens | U.S. 76/178, 6E Anderson |
| 253 | 20 | South Carolina 414, Tigerville | South Carolina 124, 5W Greenville |
| 254 | 11 | South Carolina 72, Greenwood | U.S. 25 Cokesbury, 8S Ware Shoals |
| 260 | 12 | South Carolina 261, Manning | SSR-323 @ Santee Dam |
| 261 | 116 | U.S. 521, 6S Camden | U.S. 701, 17S Conway |
| 262 | 15 | U.S. 601, 18E Columbia | U.S. 76/378, Garners Fy. Rd., 3E Columbia |
| 263 | 5 | U.S. 76/378, 22E Columbia | South Carolina 764, Eastover |
| 265 | 26 | South Carolina 9, Chesterfield | U.S. 601, 6N Kershaw |
| 268 | 5 | South Carolina 9/109, Mt. Croghan, 10E Pageland | South Carolina 265, 9E Jefferson |
| 269 | 12 | U.S. 321, 4S Winnsboro | South Carolina 215, 15N Columbia |
| 274 | 16 | U.S. 21 Bus., Rock Hill | NC Border, 10S Gastonia, NC |
| 277 | 8 | U.S. 76 (Corner of Elmwood Ave. & Bull St.), Columbia | I-77, 7 NE Columbia |
| SC DOT purchased right-of-way and planned on an extension connecting S.C. 277 with Interstate 126 in the the 1970’s. Due to neighborhood opposition, this plan was delayed and finally cancelled in the early 1980’s. The right-of-way was returned (“leased for $1”) to the city of Columbia in 2001. SCDOT however still reserved the right to complete the highway on the original right-of-way, should it be needed in the future. This highway was never designated as designated Interstate 277. | |||
| 280 | 4 | U.S. 21, Burton, 3W Beaufort | South Carolina 802, 3W Port Royal |
| 281 | 3 | U.S. 21, Beaufort | South Carolina 802, Port Royal |
| 283 | 18 | U.S. 221, Plum Branch, 5S McCormick | U.S. 25, 4NW Edgefield |
| 284 | 19 | South Carolina 20/252, 6S Belton | South Carolina 81, 9N Calhoun Falls |
| 288 | 16 | U.S. 276, Marietta, 5NW Travelers Rest | U.S. 178, 9N Pickens |
| 290 | 33 | U.S. 221, Moore, 10S Spartanburg | U.S. 25, 6N Travelers Rest |
| 291 | 9 | U.S. 276/US-25 Bus/SC-253, 2N Greenville (Pleasantburg Dr.) | U.S. 25 Bus. @ Interstate 85 Exit #45, 2S Greenville |
| 292 | 16 | South Carolina 9, 5NE Inman | South Carolina 290, Duncan |
| 295 | 17 | Bus. Loop Interstate 85 Exit #3, 3NW Spartanburg | U.S. 176, 3W Pacolet |
| 296 | 22 | U.S. 176, Spartanburg | South Carolina 14, 3E Mauldin |
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 300 | 11 | U.S. 301/321, Ulmer, 9NE Allendale | U.S. 278, 4S Barnwell |
| 302 | 67 | U.S. 176/321, W. Columbia | South Carolina 125, 5NW Jackson |
| 303 | 14 | U.S. 17A, Walterboro | U.S. 17, Green Pond, 10W Jacksonboro |
| 304 | 5 | South Carolina 70, Hilda | South Carolina 3, Blackville |
| 308 | 9 | South Carolina 72, Clinton | U.S. 221, Ora, 8N Laurens |
| 310 | 8 | South Carolina 6, 1N Vance | U.S. 176, 1NW Holly Hill |
| 311 | 9 | South Carolina 6, 2S Cross | U.S. 176, 6SE Holly Hill |
| 314 | 2 | U.S. 176, 2NW Holly Hill | U.S. 15, 5W Holly Hill |
| 319 | 13 | U.S. 501, Aynor | U.S. 701, Homewood, 2N Conway |
| 322 | 27 | U.S. 21 Bus., Rock Hill | South Carolina 49 Bullock Cr., 5N Lockhart |
| 324 | 14 | South Carolina 72/121, 6SW Rock Hill | South Carolina 5 Bus., 1E York |
| 327 | 23 | I-95 Exit #170, 7NE Florence | U.S. 52/301, Effingham, 10S Florence |
| 329 | 6 | South Carolina 18, 3NE Gaffney | South Carolina 105, 5SE Gaffney |
| 332 | 19 | U.S. 301/601, 2E Cope | South Carolina 4, 3E Springfield |
| 333 | 3 | U.S. 321, Scotia | U.S. 601, Furman |
| 336 | 15 | South Carolina 462, 7E Ridgeland | U.S. 321, 13N Hardeeville |
| 340 | 12 | South Carolina 34, Darlington | South Carolina 403, 3N Timmonsville |
| 341 | 95 | U.S. 521/601, Kershaw | South Carolina 41/51, Johnsonville |
| 346 | 13 | South Carolina 341, 1N Bethune | South Carolina 903, 13N Bethune |
| 357 | 16 | Near Jct. South Carolina 11 and U.S. 176, Campobello | South Carolina 290, 1E Greer |
| 358 | 3 | South Carolina 129, 1N Lyman | South Carolina 357, 7NE Greer |
| 362 | 23 | South Carolina 212, Williams | U.S. 78, 1E Bamberg |
| 363 | 13 | South Carolina 63, 3N Varnville | U.S. 321, Luray, 8W Hampton |
| 375 | 10 | U.S. 521, 1W Greeleyville | Jct. South Carolina 377, Gourdin, 15S Kingstree |
| 377 | 16 | South Carolina 261, Kingstree | Jct. South Carolina 375, Gourdin, 15S Kingstree |
| 381 | 20 | NC Border, 7NW McColl | South Carolina 38, Blenheim, 8S Bennettsville |
| 385 | 11 | South Carolina 79, 11N Bennettsville | U.S. 15 Bus., Bennettsville |
| 389 | 14 | South Carolina 39, 1N Perry | U.S. 321, Neeses |
| 391 | 35 | U.S. 76, Prosperity | South Carolina 39, 10S Batesburg-Leesville |
| 392 | 4 | U.S. 1, 4SW Monetta | South Carolina 23/39, Ridge Spring |
| 394 | 23 | U.S. 178, 2W North | South Carolina 302, Kitchings Mill, 13E Aiken |
| 395 | 15 | South Carolina 34 Bus., Newberry | South Carolina 194, 11NE Saluda |
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 400 | 12 | South Carolina 4, 4W Orangeburg | U.S. 321, Norway |
| 402 | 16 | U.S. 17A/US-52, 2NE Moncks Corner | South Carolina 41, Huger, 20N Mt. Pleasant |
| 403 | 36 | U.S. 15, 5S Hartsville | South Carolina 341, 4NW Lake City |
| 410 | 18 | NC Border, 6N Loris | U.S. 701, 10N Conway |
| 412 | 7 | South Carolina 81, Starr, 10S Anderson | U.S. 29, 12SE Anderson |
| 413 | 17 | U.S. 76/178, 4SW Belton | South Carolina 81, Iva |
| 414 | 16 | South Carolina 14, Gowensville, 11N Greer | U.S. 276, Marietta, 4NW Travelers Rest |
| 417 | 21 | U.S. 276, Mauldin | South Carolina 296, 7W Spartanburg |
| 418 | 26 | U.S. 221, 1NW Woodruff | U.S. 25, 5E Pelzer |
| 419 | 6 | SSR 25, Ft. Motte, 8NE St. Matthews | SC 267, 10E St. Matthews |
| 420 | 5 | U.S. 25, Shoals Jct., 6N Hodges | South Carolina 252/US-25 Bus., Ware Shoals |
| 421 | 14 | South Carolina 118, 4W Aiken | U.S. 278, 1S North Augusta |
| 430 | 12 | South Carolina 23, 2E Edgefield | U.S. 378, 10W Saluda |
| 441 | 18 | U.S. 15, Manville, 8SW Bishopville | U.S. 76/378, 10W Sumter |
| 453 | 14 | South Carolina 6, Eutawville | U.S. 178, Harleyville |
| 462 | 40 | U.S. 278, 12E Hardeeville | U.S. 321, Robertville, 19NW Ridgeland |
| 512 | 24 | South Carolina 513, 8S Hemingway | U.S. 52, Cades, 7S Lake City |
| 513 | 10 | South Carolina 41, 9S Hemingway | South Carolina 261, 10E Hemingway |
| 517 | 4 | U.S. 17, Mt. Pleasant | South Carolina 703, Isle of Palms |
| 522 | 30 | South Carolina 97, Liberty Hill | NC Border, 13NE Lancaster |
| 527 | 71 | South Carolina 341, Wisacky, 6SE Bishopville | South Carolina 41, 4N Andrews |
| 541 | 10 | U.S. 52, Coward, 7N Lake City | South Carolina 341, Olanta, 7NE Turbeville |
| 544 | 16 | U.S. 501 Bus., 2SE Conway | U.S. 17, 1N Surfside Beach |
| 552 | 7 | South Carolina 49/274, L. Wylie, 12SE Gastonia, NC | South Carolina 55, 2E Clover |
| 555 | 12 | U.S. 21, 3S Blythewood | U.S. 76, Gervais St., Columbia |
| 576 | 3 | U.S. 501 Bus./SC-41A, 2SE Marion | U.S. 76, 1W Marion |
| Route | Approx. Mileage: |
Begin | End |
|---|---|---|---|
| 602 | 13 | U.S. 1, West Columbia | South Carolina 6, Red Bank, 6S Lexington |
| 641 | 22 | U.S. 301, 2NE Allendale | South Carolina 64, Ashton, 21W Walterboro |
| 642 | 20 | U.S. 52/78, Rivers Ave., N. Charleston | U.S. 17A, 7SW Summerville |
| 651 | 8 | U.S. 61, 7E Canadys | U.S. 17A, 1W Cottageville |
| 652 | 11 | U.S. 278, 4N Ridgeland | U.S. 601, Pineland, 20S Hampton |
| 692 | 9 | U.S. 178, 3E North | U.S. 321, Swansea |
| 700 | 21 | South Carolina 171, Folly Road, James Island | Rockville, 25SW Charleston |
| 702 | 19 | South Carolina 39, 4NW Saluda | South Carolina 246, 3N Ninety-Six |
| 703 | 13 | U.S. 17/701, Mt. Pleasant | N end of Isle of Palms |
| 707 | 15 | U.S. 17, 3W Myrtle Beach | U.S. 17 Bus., Murrells Inlet |
| 742 | 4 | NC Border, 6N Chesterfield | South Carolina 145, 2N Chesterfield |
| 760 | 2 | U.S. 76/378, Garners Fy. Rd., Columbia | Fort Jackson |
| 763 | 14 | U.S. 378, 2E Sumter | South Carolina 261, Wedgefield, 9W Sumter |
| 764 | 9 | U.S. 601, 2E Eastover | U.S. 76/378, 15E Columbia |
| 768 | 5 | U.S. 76/378, Garners Fy. Rd., 6E Columbia | South Carolina 48, Bluff Rd., 4SE Columbia |
| 769 | 10 | U.S. 76/378, Horrell Hill, 12E Columbia | South Carolina 48, Gadsden, 18E Columbia |
| 773 | 5 | U.S. 176, Pomaria | U.S. 76, 3E Prosperity |
| 781 | 4 | U.S. 78, 3W Williston | U.S. 278, 7W Williston |
| 802 | 17 | Wilkins, Lady’s Island, 10E Beaufort | South Carolina 170, 7W Beaufort |
| 823 | 11 | South Carolina 81, Mt. Carmel | South Carolina 72, 4 SW Abbeville |
| 901 | 35 | South Carolina 5, 2W Rock Hill | South Carolina 200, 10N Winnsboro |
| 903 | 25 | U.S. 521 Byp., Lancaster | South Carolina 151, 6S Jefferson |
| 905 | 24 | NC Border, 4NE Longs | U.S. 501 Bus., Conway |
| 908 | 8 | U.S. 378, Britton’s Neck, 17W Conway | U.S. 41, 4S Centenary |
| 909 | 12 | U.S. 321, Lowrys, 8N Chester | South Carolina 9, 6W Richburg |
| 912 | 8 | South Carolina 9, 7NW Bennettsville | U.S. 15/401, 7NE Society Hill |
| 914 | 1.7 | South Carolina 200, 1.9W Lancaster | South Carolina 9 Business, 2.8SW Lancaster |
| 917 | 41 | South Carolina 38, 5W Latta | South Carolina 9 Bus., 6W Loris |