Different Route Ends With Different Character

[Ian]

A few I can think off the top of my head...

-NJ 72. To the west, it ends at a traffic circle with NJ 70 in the middle of the Pine Barrens as a two-laner, while to the east, it ends in the middle of Ship Bottom on Long Beach Island as one way street pairs.
-MA 2. To the west, it ends at the New York state line as a two lane mountain road, while to the east, it ends as one way street pairs right in Boston.
-US 222. To the south, it ends as a rural two lane road at US 1 in Conowingo, MD. To the north, it ends as an expressway type road at I-78 near Allentown.

[MDOTFanFB]

Here's some more that I know of.

• I-275 west of Detroit. It starts out with four lanes at a modified trumpet interchange with I-75 in rural Monroe County and ends in a concurrency with I-96 in the midst of a massive interchange also involving M-5 and I-696, in between passing by Detroit Metro Airport and through Detroit's fast-growing far western suburbs.
• U.S. 12. It begins at U.S. 101 as one-way pairs in the southern Olympic Peninsula town of Aberdeen, WA and ends as a six-lane road (with a left turn lane) deep in downtown Detroit, basically starting out lined with small one-story stores and ending lined with large skyscrapers.
• OH 2. It starts out at the Indiana state line northeast of Fort Wayne, IN as a rural two-lane road and ends in Cleveland's far eastern suburbs at U.S. 20 as a four-lane freeway, in between running diagonally through the western Ohio countryside, then through Toledo and then along the southern shore of Lake Erie.

[Alps]

NJ:
NJ 7: 2-lane road at a county line at one end, 4-lane freeway (pending new bridge construction) at the other
US 9: Ferry at one end, 14-lane 2-level bridge at the other
NJ/NY/PA 17: Freeway at one end, 2-lane town road at the other (note: This works equally well for just plain NJ 17)
NJ 29: 4-lane freeway at one end, town-maintained 2-lane with a stop sign at the other
US 46: 2-lane road ending at a state highway at one end, 14-lane 2-level toll freeway bridge ending at the state line at the other
NJ 55: 2-lane road running straight into a different state highway at one end, 4-lane suburban freeway with a directional interchange at the other
NJ 72: 2-lane rural pine barrens road at one end, 6-lane one-way pair in a shore town at the other
I-76: Continues as a 4-lane divided rural US highway at one end; 8/10 lane four-carriageway highway continuing as a 8-lane state urban freeway at the other (note, I also included this under Same Character, just because I can do these things)
I-78: Rural 4-lane Interstate interchange at one end, VERY urban tunnel entrances at the other in NYC
NJ-NY 94: One end is a toll bridge with a grade-separated interchange, the other is a signalized intersection with a yellow yield just beyond.
I-95: One end is an urban merge with a US highway, the other turns into a rural divided highway in a different country
NJ 120: One end is a 6-lane freeway interchange with another freeway in the swamp, the other is a 4-lane street interchanging with a signalized arterial in a suburb
NJ 129: Two lane barely traveled road in the backwater at one end, four-lane expressway at a freeway interchange at the other
NJ 147: 2-lane rural route on one end, multi-lane city street at the other
NJ 167: One end is a dead-end, the other end isn't. What more do you want?
NJ 171: One end is an expressway interchange with multiple lanes on all approaches, the other is along a 2-lane city street at a county-maintained road with.
NJ 172: Short as it is, one end is a four-lane divided road with an interchange at a state freeway, the other end is a 2-lane city street at a signalized intersection with other city streets
NJ 173: One end is a multilane merge with a US highway in a fairly rural area. The other is a 2-lane road ending awkwardly above a state highway that's only divided to show off within that particular interchange in a developed town.
US 202 (NJ): One end is a rural 4-lane freeway with a toll bridge, the other is a suburban 2-lane street near a train station.
I-278: One end is a lightly used stub, the other is one of the most trafficked interchanges in the nation. For an Interstate, it's hard to get more different than that.

[roadman65]

FL 528 ends at an interchange with an interstate at one end, and ends at another interchange at the other with a state route  that is non freeway and  had been concurrent  with (its east end used to be an intersection).
FL 826 ends as a freeway signed as N-S at one end, and the other end as arterial signed E-W.
US 192 ends at a trumpet interchange on one end and at an at grade intersection at the other.
FL 44 ends at a US Route (actually two routes concurrent) and at its other end at no route numbers.
FL 19 ends at a route that is a one way pair of streets and at the other a route that is on a two way  divided highway.
FL 80 ends at a partial interchange with US 41 while its other end is at a traffic circle with FL A1A.
I-4 begins at a three digit interstate and ends at a two digit interstate.
FL 435 has an interchange at one end and an at grade intersection at the other.
FL 536 ends at a major at grade intersection and a property line (WDW) at its other end.
FL 40 ends in a small city at one end and a large one at the other.

[sp_redelectric]

U.S. 30 - western end a sleepy Astoria, Oregon; the eastern end the casino town of Atlantic City

U.S. 20 - western end in small town Newport, Oregon; the eastern end Boston, Massachusetts.

U.S. 93 - on the U.S./Canadian border in Montana, a heavily forested, rural, remote area at the north; in the high desert of suburban Maricopa County, Arizona to the south.