America's Main Street?

[frankenroad]

I'd give strong consideration to US-6 and US-50, especially if you included California's decommissioned sections of both.

[Max Rockatansky]

I'd give strong consideration to US-6 and US-50, especially if you included California's decommissioned sections of both.

US 50 is pretty strong as is, the western terminus is at the State Capitol of Sacramento.  The extension over Altamont was kind of wonky in a geographic sense and a marginally better solution than US 48 (which should have been extended over Carson Pass instead IMO).

[sparker]

I'd give strong consideration to US-6 and US-50, especially if you included California's decommissioned sections of both.

US 50 is pretty strong as is, the western terminus is at the State Capitol of Sacramento.  The extension over Altamont was kind of wonky in a geographic sense and a marginally better solution than US 48 (which should have been extended over Carson Pass instead IMO).

At the time that US 48 existed, Carson Pass was not yet being plowed in winter months and was effectively closed from November through April; it wasn't until the '60's that CA 88 became a year-round (except in extremely severe storm conditions) facility.  Chances are that because of this there was never any thought to extending US 48 over then-CA 8 east of Stockton in the early '30's.  As far as the concept of extending US 50 to the coast over the convoluted "detour" south along US 99 is concerned -- the push for US routes ending in zero to, as much as feasible, extend from coast to coast (cf. US 20 in OR and US 70 in SoCal) was likely a deciding factor in the designation of the extension -- particularly after plans for the Bay Bridge were announced around 1930. 

[Flint1979]

US-40

Oh wait I didn't see it had to be an Interstate. Then I'm going with the Interstate that parallels it for most of it's length, I-70.

[mrsman]

I would pick I-80 as it is the closest interstate routing that we have to the Lincoln Highway.  But I would really pick the Lincoln Highway if that was a choice.

https://www.lincolnhighwayassoc.org/map/

Coast to coast from Times Square to the Golden Gate.

Lincoln Hwy hits NYC, Newark, Trenton, Phil, Pitts, Canton, Fort Wayne, South Bend, Chicago suburbs (auxiliary routes hit Chicago proper), Cedar Rapids, Omaha, Grand Island, Cheyenne, Salt Lake City, Reno, Sacramento, San Francisco.  Not only does it hit those cities, but it conceivably hits many mid sized towns right through its center.  Especially, the original routing before all the bypasses hit.  It even hits Breezewood.

[bing101]

US-1 on the east coast would be my pick for America's main street.
US-101 would be the west coast version of America's main street.
Note US-99 would have been another pick for the west coast version of Main street if it was not decommissioned and renumbered as state routes CA-99 and WA-99.

[SkyPesos]

If we can include non-interstates, I'll go with the Victory Highway (roughly US 40) for E-W and the Dixie Highway western route (roughly US 41) for N-S. As for their equivalent interstates, for the Victory Highway, it's I-80 SF-SLC, I-70 Denver-Baltimore, and I-95 Baltimore-NYC, and a gap between SLC and Denver as US 40 between those two is independent. For the Dixie Highway, it's roughly I-75 Miami-Chattanooga, I-24 Chattanooga-Nashville, I-65 Nashville-Gary, I-94 Gary-Chicago.

[Occidental Tourist]

I-481 in Syracuse

[JoePCool14]

Interstate 180.

[gr8daynegb]

Interstate 180.

I nominate I-535

If Bob Uecker can get HOF votes as a player anything is possible

[hobsini2]

Interstate 180.

I nominate I-535

If Bob Uecker can get HOF votes as a player anything is possible

for Bob Uecker