A lengthy state route, SR 69 originates at SR 177 in the Clark County seat of Jackson. Following a northerly course, SR 69 traverses rural areas of the Black Belt region to Tuscaloosa, where it combines with I-359 and U.S. 43. Northern reaches of the route extend to U.S. 431 at Guntersville.
South
SR 69 (Coffeeville Road) spurs 0.6 mile south from the grade separated intersection with U.S. 43 to SR 177 (College Avenue) north of Downtown Jackson. SR 177 represents the former alignment of U.S. 43 through Jackson.