U.S. 25/301 North - Statesboro

Leaving the diamond interchange (Exit 116) with Interstate 16 on U.S. 25/301-SR 73 north.
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SR 46 meets U.S. 25/301 east of the rural town of Register.
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Paralleling Interstate 16, SR 46 travels west to Metter and southeast to SR 67 near Denmark.
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Langston Chapel Road is a minor arterial heading 3.83 miles east from U.S. 25/301 to Harville Road near SR 67.
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U.S. 25BY/SR 67BY separate from U.S. 25/301 along Veterans Memorial Parkway to the north while U.S. 301BY/SR 67BY-73BY line the controlled access arterial to the east.
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U.S. 25 Bypass circumvents Downtown Statesboro around the west side of the city 4.91 miles north to U.S. 25/80.
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U.S. 301 Bypass encircles the east side of Statesboro for 6.82 miles by Allen E. Paulson Stadium at Georgia Southern University to U.S. 301 on Parrish Street.
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U.S. 25/301-SR 73 continue northeast along S Main Street by the campus of Georgia Southern University.
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Old Register Road represents the main entry point to Georgia Southern University from U.S. 25/301 (S Main Street).
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SR 67 (Statesboro Road) converges with U.S. 25/301 (S Main Street) northwest from Pembroke.
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SR 67 combines with U.S. 25/301-SR 73 (Main Street) north 1.12 miles to U.S. 80/SR 26 (Northside Drive). SR 67 is the counterpart of U.S. 25 north to SR 121 in Jenkins County.
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E Main Street was formerly part of SR 24 east from U.S. 25/301-SR 67 in Downtown Statesboro 1.74 miles to U.S. 301 Bypass (Veterans Memorial Parkway).
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U.S. 25/SR 67 part ways with U.S. 301/SR 67 to accompany U.S. 80/SR 26 (Northside Drive) northwest 6.52 miles to Hopeulikit.
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U.S. 80/SR 26 travel southeast from Statesboro to Savannah and west to Twin City and Swainsboro.
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