| Within the city of High Springs, U.S. 41 (High Springs Main Street) separates from U.S. 27 at SR 20. The route proceeds three blocks north to combine with U.S. 441 at CR 236. 01/16/16 |
| Leading northwest from CR 236 (High Springs Main Street), U.S. 41/441 run along a divided four lane arterial by the High Springs Sports Complex. Lake City lies 26 miles to the north. 11/10/06 |
| Spanning the Santa Fe River, U.S. 41/441 enter southern Columbia County. 11/10/06 |
| Initially in Columbia County, U.S. 41/441 passes through River Rise Preserve State Park. 11/10/06 |
| County Road 778 connects U.S. 41/441 with U.S. 27, 3.60 miles to the west. 11/10/06 |
| SE Sprite Loop branches east from U.S. 41/441 north to the entrance for O'Leno State Park. The state park abuts River Rise Preserve State Park to the north along the Santa Fe River. 11/10/06 |
| SE Sprite Loop Road returns to U.S. 41/441 north from O'Leno State Park. 11/10/06 |
| CR 18 ties into U.S. 41/441 north east from Fort White. 11/10/06 |
| The western leg of CR 18 measures 6.37 miles in length between U.S. 41/441 and U.S. 27 in the town of Fort White. 11/10/06 |
| CR 18 shares an implied overlap with U.S. 41/441 north for 1.1 miles. 06/29/17 |
| Lake City is 18 miles to the north of CR 18 west. 06/29/17 |
| Entering the rural community of Mikesville. 06/29/17 |
| County Road 18 continues east from U.S. 41/441 to Union County and Worthington Springs. 06/29/17 |
| CR 18 travels 11.01 miles east from U.S. 41/441 to SR 121 north of Worthington Springs. SR 18 continues east from SR 121 to Brooker. 06/29/17 |
| Continuing north from CR 18, SW Minter Road and Mikesville on U.S. 41/441. 11/10/06 |
| Despite paralleling Interstate 75 northward from South Florida, the exchange with U.S. 41/441 south of Ellisville is their lone meeting within the Sunshine State. 11/10/06 |
| U.S. 441 previous crossed paths with I-75 at Alachua. 11/10/06 |
| Low clearance overpasses take the I-75 roadways across U.S. 41/441 at a diamond interchange. 11/10/06 |
| I-75 stays west of U.S. 41/441 as both highways advance north toward Lake City. 11/10/06 |
| U.S. 41/441 intersect the west end of SR 238 to the immediate north of Interstate 75. 11/25/12 |
| State Road 238 leads 15.46 miles east to SR 100 in Union County seat of Lake Butler. 11/10/06 |
| Lake City is 14 miles north of SR 238 via U.S. 41/441. Located northwest of Lake City along U.S. 41, White Springs is 26 miles away. 11/10/06 |
| CR 240 travels 11.87 miles west from U.S. 41/441 to SR 47 at Columbia City and SR 247 near the Suwannee County line. 11/10/06 |
| Myrtis Road links U.S. 41/441 with CR 245, 1.40 miles to the east. Myrtis Road is inventoried as part of CR 240, but not signed. 11/10/06 |
| Upcoming Alfred Markham Street is inventoried by FDOT as CR 133C, but signed as CR 133 from U.S. 41/441. 11/10/06 |
| CR 133C turns north onto Country Club Road from Alfred Markham Street nearby. The 6.88 mile long route extends to U.S. 90 in Lake City. 11/10/06 |
| CR 242 stems west from U.S. 41/441, 2.20 miles to SR 47 near the exchange with Interstate 75. The county road concludes at the Suwannee County line in 11.05 miles. 11/10/06 |
| CR 252 ties into U.S. 41/441 from the southeast just ahead of their separation into Lake City. 06/30/17 |
Page Updated 05-18-2020.