U.S. 410 originally traveled between Aberdeen, Washington and Lewiston, Idaho. The designation was vastly replaced by an extension of U.S. 12 west in 1967. From west to east, U.S. 410 followed what later became U.S. 12 between Aberdeen and Elma, SR 8 from Elma to Mud Bay, with U.S. 101 from Mud Bay to Olympia, with U.S. 99 from Olympia to Tacoma, SR 167 from Tacoma to Sumner, SR 410 from Sumner to Naches, and U.S. 12 from Naches to Lewiston.
The route shared alignments with U.S. 99 east of Downtown Olympia to Tacoma and west from Downtown to Mud Lake with U.S. 101. When U.S. 99 shifted onto Interstate 5 in 1958, U.S. 410 was realigned from 4th Street and Pacific Avenue to a shared alignment with the new freeway along U.S. 101 and I-5 at Exit 104.1