What section of US Highway have you been on the most?

[Bickendan]

US 26, Portland
US 30, Portland isn't that far behind.

[thspfc]

US-51 on the northeast side of Madison.

[paulthemapguy]

Probably US52 on the way to work in Joliet.

[Jmiles32]

US-29 in Gainesville, VA. Literally can't leave my neighborhood without going on it. 

[sparker]

2012 to date:  US 101, generally between Gilroy and San Francisco.
2009-2012:  US 395, southern terminus to CA 58.
1997-2009:  US 101, southern terminus to as far north as I needed to go (more often than not friends in Goleta). 
1992-1997:  US 26 from downtown Portland out to Foster Road (then-GF living outside of Boring), or:
                   then-signed Business US 30/Sandy Blvd. from downtown out to about 82nd/OR 213.

Prior to that, it was all CA, and there's not been a lot from which to choose for 57 years!  Guesstimate: more US 101 than anything else. 

[US 89]

Overall for me is almost certainly US 89 near Salt Lake City, but more recently US 29/78/278 in Atlanta.

[nexus73]

101 between Coos Bay and North Bend (in Oregon).

Rick

[Takumi]

US 1/301 between Petersburg and Chester.

[OCGuy81]

In recent history, a toss up between US-20 and US-97.  The only two highways running through Bend, and I'm on them a lot.

When I lived in California, it probably was the 101.

When I lived in Wisconsin, I was on 151 through Madison a lot when I was going to school there.

[jp the roadgeek]

I would say that it's a close race among 4 candidates:

Two sections of US 5: One between the center of Wallingford and the WC Parkway, the other as part of the Berlin Turnpike

The portion of US 6 concurrent with I-84 between Farmington and downtown Hartford

US 44 in Avon/West Hartford (went to school off of there for 11 years)

[roadman65]

Well considering I live near US 92 and go to work using the latter, I would say 98 the most and 92 second.

[ftballfan]

US-31 in Manistee

[texaskdog]

I lived most of my years in Minnesota so highway 10s concurrency with 694 and 35E

[TheStranger]

US 101 between Post Street in San Francisco and Broadway in Burlingame.  At one point I used to frequent US 50 between West Sacramento and Howe Avenue, back when I lived in Sacramento, but haven't been on there nearly as much since returning to the Bay Area.

[Bruce]

US 2 on the Hewitt Avenue Trestle from Everett to Cavalero (where it splits with SR 204 and 20th Street). The westernmost section of the western section, a dangerous and congested expressway, and also home to some signage errors:

[Konza]

US 14 in the northwest suburbs of Chicago, notably between Palatine and Crystal Lake.

[plain]

Pretty sure it's US 1 for me. Even though I currently live closer to both US 60 and US 360 and actually lived on US 60 before, I've driven US 1 in several states many times over.