I-666 is my planned Washington outer beltway

.
This thread has devolved into a mix of (1) street names that do actually exist but the member neglected to bother doing a cursory Google search first, and (2) silly names that only bear resemblance to street names by the addition of "Hwy" or "St" at the end. We seem to have run out of truly clever ones.
I fell casualty to #1 with Toll Road, as it exists in Salisbury MA (I even had read about it before in this forum

). I've done several clever ones, like the full name-like Pearson S. Trail. I don't think they would name a street after a disease, and in this case the S stands for syndrome (I've seen an upcoming trail running event directly named after a disease, though). And the several memorial highways specified to meet certain conditions, such as the FritzOwl Memorial Highway being an US route, the Ethanman62187 Memorial Freeway being I-366 with an 85 mph speed limit, the TheAlan360 Memorial Goat Path being and not being a goat path, and the dzlsabe Memorial Hypotenuse cutting through neighborhoods.
And a couple more:
John Muir Freeway
Any street named after a US president in North Korea.