Vdeane --
This is free advice. It may be worth what you pay for it.

Like you, I hate uncertainty. I love it when I can get plans nailed down. Unfortunately, the current mess is not one good for folks who need certainty.
Earlier this thread you mentioned that you were looking at late April / early May for this trip. That's still some time off, and gives you the opportunity to watch and see how things develop. Be mindful of when the cancellation deadlines are for various places you might make reservations at, and you'll know when you have to commit one way or the other. I am on the road about 50% of my time normally; I'm anticipating that when I get home from my current trip, I will be staying home until May. However, I won't be canceling any travel plans until the last minute. Things could change.
Yes, it is possible that you could become sick (or be deemed sick) before your trip, and have to burn your leave days for that. It would suck, but that's life...and not really something I'd worry about until/unless it happens. I've had enough chaos, enough unplanned crap arise in my life, especially over the past few years, that learning to go with the cards you're being dealt and adapting your game strategy as necessary is a required survival skill. It sucks for people who desire certainty and like to plan...but unfortunately it's life.
It is also possible that additional controls will go up at the border. If you're going now, and the risk of that happening is a problem for you...don't go. But if this is a late April/early May trip... I think the odds are pretty good that any controls that are implemented (at the border, or as local/regional quarantine zones) will have been implemented by then.
If you are going "now", however...it wouldn't be a bad idea to put off the trip and try again later, when circumstances permit. The virus probably wouldn't affect you much if you were exposed to it, but if you came into contact with your parents while contagious.... I work in risk management in insurance, so I'm a professional worrier/pessimist. I think it's not unreasonable to avoid unnecessary travel for a couple of weeks and avoid unnecessary risks, until we have better information about what's going on. Live life, do what you have to...but make sure that what you get out of such actions is worth any additional risk you are exposed to, or that you might be exposing others to.
You also mentioned that you're concerned about losing the opportunity to clinch US 11, given an expectation of moving in the future. You are concerned that you will run into trouble if you don't have a reasonable explanation for taking that particular route. I have been slowly, quietly "collecting" border crossings, when I go to/from Montréal. If the weather's decent and time permits, I follow unorthodox commute paths. So, with that background, I can say that I don't think you have anything to worry about if you want to clinch US 11 after you've moved away. I've found "it's a nice day, and I don't want to waste it on the interstate" or "freeways are boring" are answers that border guards accept, if/when they ask. Yes, there is an increased risk of having to do a secondary inspection....but allow extra time for that, be honest, and be familiar with what you can/can't take across the border (and abide by those rules), and it's not really a big deal.
I don't know that any of that is useful to you, but I thought I'd share those thoughts on the off chance they help.