My earliest recollection is from the mid-1970's traveling between Lancaster PA (home) and Fort Lauderdale FL (grandparents), mostly along I-95. I recall the sections where the highway was not complete and we were diverted onto the parallel U.S. routes, such as U.S. 301 in Emporia, VA, and again in Rocky Mount, NC, and again in Fayetteville, NC; U.S. 15 at I-26 in SC, U.S. 17 in SC and GA (Savannah area and Brunswick), and Florida's Turnpike froom Vero to West Palm. I recall being excited when I-95 was completed in Broward County.
First long trip behind the wheel was roughly the same trip during the overnight hours. Fell asleep behind the wheel briefly in SC, and the shoulder rumble strips did their job and woke me up, saving me from a much worse fate.