I have never done that (I've always had a destination much further west than Bedford), though some folks have insisted that U.S. 30 is not that much slower than the E-W mainline of the Turnpike from Breezewood to Pittsburgh.
The friends I rode to Chincoteage, VA with (from Pittsburgh) this past summer opted to take US-30 (though using the TPK to Irwin first) to Breezewood. Not sure if avoiding tolls was the primary motivating factor or not. I know the ladyfriend (I was with an engaged couple) drove the first shift to Breezewood, and talked about how she hated the Turnpike. The trip home was just a reverse route, using US-30 again.
It wasn't too bad for most of the trip heading to the beach. It was pretty early ( ~7:00am) when we were in Irwin, so we got a lot of green lights. Though we did end up following some slow-pokes west of Bedford.
Coming home was a bit different. It was about late afternoon on Saturday, more traffic, more "reds", and it took a good bit longer.
I wasn't in a hurry, so I didn't mind checking out some stretches roads I hadn't been on in years. But if I were driving, I doubt I'd do that again, and just shell out for tolls and just take the Turnpike. Though I sometimes take PA-51/US-40/I-68 (would probably start adding Tpk-43 into that now that it's done from the South Hills to Uniontown) when heading in that direction (Baltimore/DC/Eastern Shore).
As per the topic. Growing up I can say a stop @ McDonald's in Breezewood on the way to Ocean City was a tradition for quite a few years.
Also, some friends and I had a good 7 year run of trips down to Louisville for Lebowskifests, and part of that tradition was stopping at the USA Steak Buffet in Cambridge, OH for dinner on the way down.