Interstate 172 South

Exit 2 joins I-172/IL 110 (Chicago Kansas City Expressway) south with IL 57 north to Marblehead and 1083 Lane (Old IL 57) south to nearby Fall Creek.

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The last confirming marker for Interstate 172 south precedes mile marker 2 and the 150th Avenue over crossing by Fall Creek.

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Hannibal, Missouri lies west across the Mississippi River along I-72/U.S. 36. Jacksonville and Springfield are located along the Central Illinois Expressway east.

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Interstate 172 curves southeast into the trumpet interchange at Exit 0. The Great River Road national route accompanies I-72/U.S. 36 and IL 110 (CKC) west to IL 106 near East Hannibal.

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Omitted from guide signs for Exit 0, U.S. 36 overlaps with all of Interstate 72 between Hannibal, Missouri and Decatur.

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An end shield for Interstate 172 appears at both the Fall Creek Road (Old IL 79) overpass and Pike County line.

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Exit 0 connects I-172 south with I-72/U.S. 36 west to Hannibal, Monroe City and St. Joseph, Missouri. The freeway mainline defaults onto the Central Illinois Expressway east to the Pike County seat of Pittsfield.

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MSR 110, the Chicago Kansas City Expressway, turns west alongside U.S. 36 to Interstate 35 at Cameron, Missouri.

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