Interstate 376 East - Sharon to New Castle

Exit 1B loops onto I-80 east toward Mercer from the cloverleaf interchange joining PA 760 south with Interstate 376 eastbound.
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Exit 1C departs I-376 just south of I-80 for PA 318 (Mercer West Middlesex Road).
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PA 18 heads south from West Middlesex to connect with PA 551 (Pulaski Road) and I-376 at Exit 2.
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PA 18 (New Castle Road) joins the borough of West Middlesex with Wilmington township to the southeast.
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Continuing south from Shenango township, Interstate 376 reaches the city of New Castle in 13 miles.
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PA 208 travels west from the borough of New Wilmington to meet Interstate 376 at a diamond interchange (Exit 5).
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PA 208 (Pulaski Road) combines with PA 551 just west of I-376 through the community of Pulaski.
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Interstate 376 enters Lawrence County and Pulaski township alongside PA 551 (Mercer Road).
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PA 208 concludes to the west beyond New Bedford at U.S. 422 by the Ohio state line. PA 208 east leads to Westminster College in New Wilmington and Volant.
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I-376 angles southeast to Neshannock township and Mitchell Road.
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Mitchell Road (SR 4012) links I-376 with PA 18 (Wilmington Road) and Mercer Road (SR 1005) at Pearson Park.
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Pulaski Road provides the connection from I-376 east to U.S. 422 (Benjamin Franklin Highway) west to Youngstown, Ohio in lieu of a direct ramp at Exit 12.
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Exit 12B loops onto U.S. 422 Business (Sampson Street) east. Founded at the confluence of the Shenango River and Neshannock Creek in 1798, the city of New Castle became a borough in 1825. It was transferred to new Lawrence County in 1849 and became a city in 1869. Steel mills brought prosperity and population to the city, with as many as nearly 40,000 people living in New Castle at one point.
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Interstate 376 combines with U.S. 422 along the New Castle Bypass through Union township.
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U.S. 224 (State Street) meets I-376/U.S. 422 at Exit 13 between Parkstown and Oakwood.
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U.S. 224 extends east along Street to U.S. 422 Business (Sampson Street) in New Castle. The two routes combine along Falls Street to PA 18 (Jefferson Street) in Downtown.
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Originating in New Castle, U.S. 224 travels west to Poland, Ohio and overall to U.S. 24 in Huntington, Indiana.
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Interstate 376 splits with U.S. 422 east along the tolled Beaver Valley Expressway at Left Exit 15.
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U.S. 422 continues east through New Castle and by South New Castle along a freeway bypass en route to Butler.
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