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East
E Charles Street (SR 3002), the former alignment of U.S. 522, stems west from a wye interchange on U.S. 22/322 east.
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U.S. 22/322 continue 60 miles south from the Green Avenue (SR 2004) overpass outside Lewistown to Harrisburg.
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U.S. 22/322 converge with the east end of U.S. 22 Business at a wye interchange alongside the Juniata River.
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Entering Juniata County and Fermanagh township, U.S. 22/322 become the Dr. L.G. Guiser Memorial Highway.
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U.S. 22/322 spans Butcher Shop Road (SR 4008) ahead of a diamond interchange with PA 35.
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PA 333 meets U.S. 22/322 at the borough of Thompsontown two miles ahead.
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The borough of Newport lies southwest of U.S. 22/322 along PA 34 at the Juniata River.
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U.S. 22/322 turns east into Howe Township ahead of a diamond interchange with PA 34.
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Page Updated Monday February 08, 2021.