U.S. 45 North - Quitman to Meridian

U.S. 45 converges with the north end of MS 145 from Shubuta beyond Shubuta Creek.
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U.S. 45 encircles the census designated place of De Soto ahead of a folded diamond interchange with MS 145 to Quitman.
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Following High Street through De Soto, MS 145 originates 1.55 miles to the south of the exchange with U.S. 45. This part of the highway is unmarked as MS 145.
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Connecting with MS 18 west to Pachuta, MS 145 continues north along the old alignment of U.S. 45 into the Clarke County seat of Quitman.
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Advancing northeast from De Soto, U.S. 45 spans the Chickasawhay River for the second time.
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County Road 110 meanders northwest from U.S. 45 to Archusa Creek Water Park in the city of Quitman.
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U.S. 45 connects with MS 511 at a grade separated intersection with an access road in the southwest quadrant of the exchange.
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MS 511 spurs 6.60 miles from MS 18 in Quitman to areas of timberland southeast of U.S. 45.
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MS 18 branches northeast from MS 511 and Archusa Creek Water Park to a diamond interchange with U.S. 45.
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East from U.S. 45 and Quitman, MS 18 is a rural highway concluding at the Alabama state line and County Route 20.
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MS 145 arcs northeast from Quitman to cross U.S. 45 near Clarkco State Park.
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MS 145 shifts east of U.S. 45 northward to the settlement of Union.
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U.S. 45 crosses Rolling Creek between intersections with County Road 150.
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MS 514 converges with U.S. 45 at the rural settlement of Roy.
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MS 514 runs west from U.S. 45 to MS 513 in the town of Enterprise.
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County Road 350 leads southwest from MS 514 to the town of Stonewall.
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MS 514 concludes 2.02 miles to the east of U.S. 45 at MS 145 and Union.
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MS 145 meets U.S. 45 again northwest from Union and south of Clarkdale.
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MS 145 continues north to Clarkdale High School on a parallel course to U.S. 45 into Lauderdale County.
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Cross traffic was eliminated at MS 145 near Clarkdale with the implementation of an RCUT intersection in 2018.
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Without direct access from U.S. 45, MS 145 angles northeast across the expressway to Stinson and Wolf Springs.
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Passing west of Stinson, U.S. 45 upgrades to a freeway ahead of the diamond interchange with MS 145 at Wolf Springs.
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MS 145 spurs northward from U.S. 45 and Wolf Springs to I-20/59-U.S. 11/80 in the city of Meridian.
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Causeville Road extends southeast from 22nd Avenue Heights in Meridian to a diamond interchange with U.S. 45.
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U.S. 45 runs through eastern reaches of the Meridian city limits from north of Causeyville Road to U.S. 11/80 beyond I-20/59.
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MS 19 combines with I-20/59-U.S. 11/80 to the west of a diamond interchange with U.S. 45. The state highway follows the freeway across Meridian before turning northwest toward Philadelphia.
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MS 19 travels southeast to becomes Alabama State Route 10. SR 10 continues the route to SR 17 at Butler.
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A cloverleaf interchange joins the freeway along U.S. 45 with I-20/59 in a quarter mile.
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I-20/59 overlap northeast from Meridian to Tuscaloosa and Birmingham, Alabama.
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I-20/59 cross Meridian west before parting ways on respective courses to Jackson and Hattiesburg.
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