U.S. 49 South - Richland to Mendenhall

South from the separation with I-20 east, U.S. 49 is a limited access expressway to Old Highway 49 in Richland.
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U.S. 49 continues seven miles through the Jackson county suburbs south to the city of Florence.
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Right in right out (RIRO) ramps link southbound U.S. 49 with W Frontage Road and the adjacent industrial area.
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Old Highway 49, unsigned MS 149, converges with U.S. 49 south at the end of the expressway.
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Old Highway 49 (MS 149) runs 3.03 miles north to U.S. 80.
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U.S. 49 transitions to a six-lane arterial and next intersects McBride Street west and Quinn Drive east.
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U.S. 49 south at Harper Street in Richland.
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The succeeding traffic light on U.S. 49 south in Richland operates at Scarborough Street west and Wilson Drive east.
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2019-22 construction expanding U.S. 49 to six lanes included realigning Monterey Road northward to intersect U.S. 49 across from Cleary Road.
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Continuing south into the city of Florence, U.S. 49 converges with MS 469 (E Main Street) east of Downtown.
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MS 469 travels northeast to MS 468 near Brandon and south to MS 28 in Simpson County.
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U.S. 49 runs along the east side of the unincorporated community of Star to Main Street and Star Road.
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U.S. 49 enters Simpson County south of Piney Woods.
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MS 149 branches south from U.S. 49 to the village of Braxton.
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Walnut Street extends south from U.S. 49 and St. John Road into the town of D'Lo.
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MS 13 meets U.S. 49 at a diamond interchange along the north side of Mendenhall in a half mile.
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MS 13 travels northeast to the village of Puckett and south from Mendenhall to Prentiss and Columbia.
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MS 540 branches east from nearby MS 149 in south Mendenhall to intersect U.S. 49.
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MS 540 connects Mendenhall east with Raleigh in Smith County.
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MS 149 from Mendenhall returns to U.S. 49 just south of MS 540.
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The next branch of MS 149 separates from U.S. 49 south to the unincorporated community of Sanatorium.
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Beyond Sanatorium, MS 149 crosses back to the east of U.S. 49 en route to the city of Magee.
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