U.S. 76/378 West

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U.S. 401 originates in Downtown Sumter at the intersection with U.S. 76 Business and U.S. 521 at Calhoun and Washington Streets.
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U.S. 15 overtakes N Main Street from Lafayette Drive ahead of the grade separation with U.S. 76/378 (Robert E. Graham Freeway).
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U.S. 15 travels north from Sumter to the Lee County seat of Bishopville, Hartsville and Bennettsville.
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Right in right out (RIRO) ramps link U.S. 76/378 with N/S Pike West, service roads connecting with U.S. 15 (N Main Street).
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U.S. 76 Business/521 (Broad Street) combine northwest from Downtown Sumter along Broad Street and separate just south of U.S. 76/378.
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U.S. 521 continues northwest from Sumter to the Kershaw County seat of Camden, Lancaster and Charlotte, North Carolina.
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A half diamond interchange joins U.S. 76/378 with U.S. 521 (Camden Highway).
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U.S. 76/378 overtake Broad Street from the Robert E. Graham Freeway and west end of U.S. 76 Business.
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The succeeding intersection along U.S. 76/378 is with S.C. 120 south along Alice Drive.
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