South 
Downtown Manning is 18 miles to the southwest of U.S. 378 in Turbeville along U.S. 301.
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Salem Road (Road 37) runs 1.30 miles east from U.S. 301 to Old Manning Road (Road 36) at the unincorporated community of New Zion.
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Connecting U.S. 52 at Kingstree with U.S. 378 west to Sumter, S.C. 527 (Black River Road) meets U.S. 301 just beyond Sardinia.
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U.S. 301 traverses Black River Swamp southwest from Gable.
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U.S. 301 Connector (Trinity Church Road) branches west from U.S. 301at Trinity Cross Roads to the unincorporated community of Alcolu. The unsigned route measures 2.43 miles in length, also following Main Street north to U.S. 521 (Sumter Highway).
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U.S. 301 curves west to intersect U.S. 521 (Sumter Highway) at June Burn Road (Road 40).
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U.S. 521 is unmarked along U.S. 301, as is the turn onto Sumter Highway for U.S. 301 southbound.
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South
U.S. 301/521 combine south ahead of the Pocotaligo River.
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Curving south onto N Brooks Street, U.S. 301/521 enter the city of Manning.
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U.S. 521 splits from U.S. 301 (Brook Street) south along Church Street. Paralleling each other, both highways lead south into Downtown Manning.
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Factoring in the bypass of Andrews, U.S. 521 travels 64 miles southeast from U.S. 301 in Manning to U.S. 17 in George Town.
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Brooks Street shifts southward at Old Georgetown Road (Road 23).
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U.S. 301 (Brooks Street) south at Rigby Street in Downtown Manning.
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South
S.C. 261 (Boyce Street) runs across Manning west to Paxville and Pinewood and east with U.S. 521 toward Kingstree.
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S Brooks Street ends at Windfield Drive where U.S. 301 turns westward.
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S.C. 260 parallels U.S. 301 south along Mill Street 0.26 miles to Winfield Drive / Sunset Drive.
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S.C. 260 spurs 12.52 miles south from S.C. 261 (Boyce Street) in Manning to Eagle Point along Lake Marion.
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U.S. 301 angles southwest along Sunset Drive ahead of the signalized intersection with Boundary Street (Road 97).
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U.S. 301 meets Interstate 95 for the first time since South of the Border to the southwest of Manning.
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A parclo A2 interchange joins U.S. 301 with Interstate 95 at Exit 115.
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U.S. 301 (Alex Harvin Highway) curves west onto Main Street into the town of Summerton.
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Passing by Summerton Town Hall and Railroad Avenue (U.S. 15 Connector), U.S. 301 converges with U.S. 15 (Church Street).
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U.S. 15/301 overlap southwest to Lake Marion. U.S. 15 north travels to Paxville and Sumter.
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South
U.S. 15/301 combine south from Church Street in Summerton 7.40 miles to Interstate 95 at Exit 102.
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Buff Boulevard (Road 102) south links U.S. 15/301 (Church Street) with Interstate 95 at Exit 108 in 0.60 miles.
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The rural settlement of St. Paul lies at the cross roads of U.S. 15/301 (St. Paul Road) and Liberty Hill Road (Road 373).
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U.S. 15/301 cross Cantey Bay, an arm of Lake Marion.
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U.S. 15/301 shift off of St. Paul Road and onto adjacent Interstate 95 to cross Lake Marion.
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St. Paul Road spurs 0.86 miles southwest to the bridge formerly taking U.S. 15/301 across Lake Marion.
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A trumpet interchange connects U.S. 15/301 with I-95 across from Dingle Pond Road (Road 400).
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U.S. 15/301 overlap with Interstate 95 south past Santee.
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Photo Credits:
01/05/19 by AARoads
Connect with:
Interstate 95
U.S. 15
Page Updated 12-07-2022.