U.S. 321 North - Hardeeville to Fairfax

U.S. 321 spans a CSX Railroad line along Deerfield Road beyond the first confirming marker in Hardeeville.
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U.S. 321 proceeds north to meet the west end of S.C. 46 at Church Road.
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S.C. 46 runs 17.33 miles east to Pritchardville and U.S. 278 at Bluffton.
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The distance sign posted north of S.C. 46 (Church Road) alludes to the former cosigning of U.S. 601 with U.S. 321 to Tarboro. U.S. 601 was truncated north in 1975.
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S.C. 336 travels east from U.S. 321 at Tillman 7.86 miles to U.S. 17/278 in Ridgeland.
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U.S. 601 (Cypress Branch Road) branches north from U.S. 321 at Tarboro to Furman and Hampton.
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The 95 miles to Augusta, Georgia cited for the north beginning of U.S. 601 implies U.S. 278 west from Hampton and S.C. 125 across the Savannah River Site (SRS) back to U.S. 278 at Beech Island.
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U.S. 321 crosses into Hampton County 24.48 miles north of U.S. 17 in Hardeeville.
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S.C. 119 extends 5.99 miles north from Georgia State Route 119 to U.S. 321 at Garnett.
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MSR 119 leads southwest to Springfield, Guyton and Pembroke, Georgia.
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S.C. 333 links U.S. 321 (Columbia Highway) in Scotia with U.S. 601 (Savannah Highway) in Furman, 3.34 miles to the east.
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U.S. 321 enters the town of Estill along Railroad Avenue.
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Railroad Avenue at 2nd Street in the Estill business district.
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S.C. 3 ties into U.S. 321 for a 0.26 mile long overlap west from 3rd Street.
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S.C. 3 continues northwest from U.S. 321 along Nixville into Allendale County at Solomons Crossroads. S.C. 3 travels north to Barnwell and back to U.S. 321 at Swansea.
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U.S. 321 (Columbia Highway) remains alongside a CSX Railroad line north from Estill into the rural town of Luray.
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S.C. 363 (Luray Highway) stems 8.06 miles east from U.S. 321 to U.S. 278 in Hampton.
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Gifford Town Hall lies on the northeast corner of the intersection joining U.S. 321 (Columbia Highway) with Hope Well Road and Phyllis Street.
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U.S. 321 straddles the Allendale County line north from the Coosawhatchie River to Fairfax.
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U.S. 321 (Hampton Avenue) north converges with U.S. 278 (Allendale-Fairfax Highway) at the Fairfax business district.
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U.S. 278 angles northwest to Allendale and southeast to Hampton.
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