U.S. 378 West - West Columbia to Lexington

U.S. 378 (Sunset Boulevard) meets Interstate 20 at a six-ramp parclo interchange (Exit 61) midway between West Columbia and Lexington.
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Corley Mill Road (Road 68) arcs 5.08 miles northwest from U.S. 378 (Sunset Boulevard) to S.C. 6 (Lake Drive) by Lake Murray Dam.
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Lexington Marketplace shopping center was constructed on the north side of U.S. 378 at Palmetto Park Boulevard in 2016/17.
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S.C. 6 combines with U.S. 378 along N Lake Drive for 0.29 miles. The arterial intersects Northwood Road (Road 392) west at Abbie Lane east.
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S.C. 6 continues south along Lake Drive to U.S. 1 in Downtown Lexington. U.S. 378 turns west along Columbia Avenue through a commercial strip.
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U.S. 1 (Main Street) heads northwest to join U.S. 378 (Columbia Avenue) west at Old Chapin Road (Road 52).
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U.S. 1/378 overlap 0.67 miles west to Gibson Road (Road 176). The two previously ran concurrent between Columbia and West Columbia.
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U.S. 378 diverges from U.S. 1 (Main Street) to the north as both proceed through the suburban areas outside the town of Lexington.
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U.S. 1 continues west from Lexington to Batesburg-Leesville while U.S. 378 reaches Saluda in 30.6 miles.
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U.S. 378 crosses the Beaverdam Creek arm of Lake Murray over Jake Knott's Bridge.
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The four lane section of U.S. 378 concludes west of Beulah Church and Priceville Roads (Road 24).
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Construction from 2017 to December 15, 2020 replaced bridges along U.S. 378 over both Horse Creek and Hollow Creek at Lake Murray.
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