U.S. 378 West - Lake City to Sumter

N Mathews Road (Road 278) intersects U.S. 378 west of the exchange with U.S. 52 on the north side of Lake City.
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U.S. 378 (Turbeville Highway) straddles the Clarendon / Florence County line west to Scurry Road (Road 972) north.
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U.S. 378 shifts off Myrtle Beach Highway northwest at S.C. 763 onto the Robert E. Graham Freeway bypassing Sumter.
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S.C. 763 extends Myrtle Beach Highway west 2.20 miles to U.S. 76 Business (Liberty Street) en route to Downtown Sumter.
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U.S. 76 (Florence Highway) west converges with U.S. 378 and U.S. 76 Business (Liberty Street) at a parclo interchange.
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The business route for U.S. 76 through Sumter loops 5.91 miles across the city.
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U.S. 76 accompanies U.S. 378 (Robert E. Graham Freeway) westbound ahead of a modified diamond interchange with U.S. 401 (Oswego Highway).
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