County Road 21 replaced Florida Secondary Road 21, which extends 8.60 miles south from SR 20 near Whiteville, east of the end of SR 21, to CR 315 at Orange Springs. The rural highway in Putnam County leads to Johnson, Higginbotham Lake, Skinner Lake before crossing into northern Marion County just ahead of Orange Springs.
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| The confirming marker posted south of CR 20A (Keuka Road) at Johnson was missing by 2022. 09/04/06 |
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| South from Tree Farm Road and the community of Johnson, CR 21 plies across areas of wetlands. 10/16/22 |
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| Curving southeast by Higginbotham Lake, CR 21 advances past Hidden Lake Trail to Skinner Lake. 10/16/22 |
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| CR 21 south ahead of Little Orange Creek. 10/16/22 |
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| Shifting east through a S-curve across Orange Creek, CR 21 enters Marion County. 10/16/22 |
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| The unincorporated community of Orange Springs lies just inside Marion County. 10/16/22 |
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| CR 315 travels southwest from Kenwood into Orange Springs, overtaking CR 21 south to Fort McCoy. 10/16/22 |
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| CR 315 travels south from Orange Springs to SR 40 near Silver Springs and north to SR 20 in Interlachen. 10/16/22 |
Page Updated 10-24-2022.
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