Interstate 57

Interstate 57

Originating in southeast Sikeston, Interstate 57 travels 22.19 miles east northeast in Missouri. The freeway extends eastward from an expressway taking U.S. 60 across the south side of Sikeston in Scott County. Crossing into Mississippi County, I-57/U.S. 60 trend northward to Bertrand. U.S. 62 parallels the pair east into Charleston, where Business Loop I-57 coincides with Route 105 (S Main Street) and U.S. 62/Route 77 (E Marshall Street) between Exits 10 and 12.

Overlapping with U.S. 62 to Wilson City and Wyatt, U.S. 60 branches east from I-57 in Charleston. I-57 angles northeast from there across the Mississippi River at Cairo, Illinois.

Future plans extend Interstate 57 west from Sikeston to Poplar Bluff along U.S. 60 and south along U.S. 67 to Little Rock, Arkansas.

Interstate 57 Missouri Guides

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Page Updated Tuesday October 31, 2023.