Interstate 81 South - Cicero to Syracuse

Reassurance shield posted south of the diamond interchange with NY 31 (Seymour Street) in Cicero.
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A cloverleaf interchange joins Interstate 85 south with I-481 south and NY 481 north at Exit 29. Through traffic to Cortland and Binghamton is directed onto I-481 to bypass the city of Syracuse.
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Exit 21N connects I-81 south with NY 481 north at North Syracuse. NY 481 extends northwest as a freeway to Fulton and from there to Oswego.
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Interstate 481 travels southeast from I-81 and NY 481 at Cicero to DeWitt and I-90 (New York Thruway).
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A guide sign for U.S. 11 stands along the off-ramp (Exit 21N) for NY 481 north. Exit 10 departs for Circle Drive, a connector linking U.S. 11 by Market Place Mall with S Bay Road.
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Destiny USA shopping mall lies between Interstate 81 and the east side of Onondaga Lake.
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I-81 and I-690 converge at an unnumbered three-wye interchange at Downtown Syracuse.
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Interstate 81 follows an elevated viaduct south from I-690 along Almond Street to Van Buren Street.
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Exit 18 joins Interstate 81 with Harrison Street west and Adams Street east for the Syracuse central business district and Syracuse University.
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A left side entrance ramp connects I-690 west with I-81 south ahead of a lane drop.
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Downtown Syracuse spreads to the west of the I-81 Viaduct. The I-81 Viaduct Project removes the elevated roadway and replaces the freeway with Business Loop I-81. The Record of Decision (ROD) for the project was signed by the Governor on May 31, 2022.
08/22/21

The succeeding exit along Interstate 81 south connects with McClure Avenue west at S State Street, one block north of Brighton Avenue.
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The I-81 Viaduct ends just beyond the New York, Susquehanna & Western Railroad west of Syracuse University.
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S State Street stems south from U.S. 11 at Raynor Avenue to the split diamond interchange at Exit 17.
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Exit 17 departs Interstate 81 south for S State Street at McClure Avenue west to U.S. 11 (S Salina Street). Brighton Avenue travels west to NY 175 (South Avenue) and southeast to I-481 and NY 173 (Seneca Turnpike).
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Interstate 81 straddles the hillside above the south Syracuse street grid along U.S. 11.
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I-81 lowers into a three-wye interchange (Left Exit 16A) with Interstate 481 east to DeWitt and north to Cicero.
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Interstate 481 arcs northeast from Syracuse to Jamesville and I-690 at East Syracuse.
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Completed in 1981, Interstate 481 was designated I-281 until 1970. Originally the bypass only extended as far north as the New York Thruway (I-90).
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A lane drop occurs at Left Exit 16 A for I-481 north. The freeway loop meets NY 5/92 in five miles near Fayetteville and the New York Thruway in nine miles.
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I-81 crosses over NY 173 (Seneca Turnpike) ahead of this confirming marker south of I-481.
05/09/05

Nedrow, a community in the town of Onondaga along U.S. 11, is three miles ahead at the succeeding exit from I-81. Binghamton is 64 miles further south.
09/27/09

A modified diamond interchange joins Interstate 81 with U.S. 11 at Exit 16. The freeway straddles the northeastern reaches of the Onondaga Indian Reservation from Nedrow south to the LaFayette town line.
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Lowering toward Exit 16, Interstate 81 passes under the Sentinel Heights Road overpass between rock cuts.
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U.S. 11 follows S Salina Street from Syracuse to Nedrow and I-81 at Exit 16. NY 11A branches southwest from U.S. 11 into the Onondaga Indian Reservation nearby.
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Continuing south from Exit 16, Interstate 81 runs between a west side frontage road and U.S. 11.
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The town of LaFayette lies four miles to the south via Exit 15. Binghamton is 63 miles away.
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