U.S. 21 South - Fort Mill to Rock Hill

Carowinds Boulevard continues 1.05 miles southeast from the North Carolina state line to become part of U.S. 21 south through the exchange with I-77.
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U.S. 21 south splits with Interstate 77 at the parclo interchange with Carowinds Boulevard.
05/30/21

A loop ramp joins Carowinds Boulevard south with I-77/U.S. 21 north into Charlotte, North Carolina.
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U.S. 21 continues south from the exchange with I-77 at Carowinds Boulevard 0.35 miles to MSR 51 west of Pineville, North Carolina.
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U.S. 21 travels 35 miles south from S.C. 160 at Fort Mill to Great Falls. Rock Hill is eight miles to the southwest along a former business route for U.S. 21.
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Harris Street (Road 100) west and Harris Road (Road 100) east come together at U.S. 21 south of the traffic light for Fort Mill High School.
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Continuing south, U.S. 21 meets the south end of U.S. 21 Business from Fort Mill at S Sutton Road (Road 49).
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U.S. 21 spans the Catawba River over the Thomas B. Spratt Memorial Bridge.
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S.C. 161 (Celanese Road) begins west from U.S. 21 at Cel-River Road (Road 50).
11/21/21

28.91 miles in York County, S.C. 161 runs west to York and north as NC 161 to Kings Mountain, North Carolina.
11/21/21

Back to back parclo interchanges link Interstate 77 with S.C. 161 (Celanese Road) and U.S. 21 (Cherry Road) in northeastern Rock Hill.
11/21/21

Future construction will rebuild the exchanges joining I-77 with Celanese Road and U.S. 21 (Cherry Road). Designs include a double diverging diamond interchange.
11/21/21

Interstate 77 runs along the east side of Rock Hill southward toward the capital city of Columbia.
11/21/21

U.S. 21 and I-77 meet again 4.4 miles to the south.
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Interstate 77 travels north from the folded diamond interchange (Exit 77) with U.S. 21/S.C. 5 (Anderson Road) at Rock Hill to Fort Mill and Charlotte, North Carolina.
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Lesslie Road (Road 6) branches southeast from U.S. 21/S.C. 5 (Anderson Road) to the unincorporated community of Lesslie. Road 6 returns to U.S. 21 in 4.26 miles at Roddey.
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Galleria Boulevard ties into the signalized intersection with Lesslie Road (Road 6) from the north.
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Continuing south from the modified diamond interchange with E Springdale Road (Road 50).
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Pantry Drive connects U.S. 21/S.C. 5 (Anderson Road) with Neely Creek Road (Road 31) at Lesslie.
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Grier Lesslie Road (Road 558) spans U.S. 21/S.C. 5 north of Roddey.
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S.C. 5 leaves U.S. 21 (Anderson Road) south at a parclo interchange.
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S.C. 5 heads 7.92 miles east from the exchange with U.S. 21 at Roddey to U.S. 521 north of Lancaster.
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