U.S. 301 North - Orangeburg to Santee

U.S. 301 (John C. Calhoun Drive) crosses a CSX Railroad line ahead of the signal with Bleakley Street (Road 95) in Orangeburg.
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U.S. 301 Truck shift southeast onto Five Chop Road ahead of U.S. 21/178/601 Truck (Joe S. Jeffords Highway/ Whittaker Parkway).
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Encircling Orangeburg, U.S. 21/178 overlap for 4.36 miles between Columbia Road and Charleston Highway. U.S. 601 Truck accompanies the five lane boulevard north from S.C. 4 to U.S. 601 on Magnolia Street.
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U.S. 301 (Five Chop Road) converges with Interstate 26 at a cloverleaf interchange (Exit 154).
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U.S. 301 (Five Chop Road) advances east from Four Hole Swamp to meet U.S. 176 (Old State Road) at Oaks Crossroads.
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U.S. 176 parallels I-26 and S.C. 6 northwest to Cameron and southeast to Holly Hill.
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S.C. 47 branches northeast from U.S. 301 along Cleveland Street 5.74 miles to S.C. 6 (Old Number Six Highway) in Elloree. Santee lies eight miles east of S.C. 47 via U.S. 301 and U.S. 15.
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Linking S.C. 6 south of Elloree with U.S. 15 by Gibson Bay, S.C. 267 follows Tee Vee Road for 5.48 miles.
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S.C. 267 provides a cut off from U.S. 301 northbound to U.S. 15 south leading to Holly Hill.
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U.S. 301 and S.C. 267 meet at a RCUT intersection.
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U.S. 15 (Bass Drive) is unmarked along U.S. 301 (Five Chop Road) northbound. U.S. 15 overlaps with U.S. 301 to I-95 while Bass Drive is unsigned U.S. 15 Connector to S.C. 6 in the town of Santee.
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U.S. 301 continues east from U.S. 15 to a six-ramp parclo interchange (Exit 97) with Interstate 95.
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Interstate 95 travels south to Walterboro and Hardeeville in South Carolina's LowCountry.
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U.S. 301 originally combined with Interstate 95 north at a wye interchange. The exchange was expanded during construction from 2013 to 2017 with access to S.C. 6 Connector (Five Chop Road).
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U.S. 301 overlaps with Interstate 95 north across Lake Marion.
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