U.S. 601 North - Tarboro to Bamberg

The first confirming marker for U.S. 601 north.
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S.C. 652 (Calf Pen Bay Road) runs 10.48 miles east from U.S. 601 to U.S 278 near Ridgeland.
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S.C. 462 (Gillison Branch Road) crosses U.S. 601, 2.52 miles east of U.S. 321.
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S.C. 462 continues 10.28 miles east from U.S. 601 to U.S. 278 south of Gray and west of Coosawhatchie.
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U.S. 601 crosses the Hampton County line 5.93 miles north from U.S. 321 near Tarboro.
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U.S. 601 (Savannah Highway) proceeds north into the town of Furman.
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S.C. 333 (Scotia Furman Highway) heads 3.34 miles west from U.S. 601 to U.S. 321 in the town of Scotia.
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S.C. 3 (Browning Gate Road) heads 3.27 miles east from U.S. 321 in Estill to meet U.S. 601 en route to Nixville.
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Crossing the Coosawhatchie River.
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Entering the town of Hampton.
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U.S. 601 follows W 1st Street north into the Hampton street grid at Holly Street.
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U.S. 601 combines with U.S. 278/S.C. 363 (Elm Street) west from the Hampton business district.
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S.C. 363 branches north from U.S. 278 (Elm Street) four blocks to the east. U.S. 278 continues southeast into the town of Varnville.
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U.S. 278/601 and S.C. 393 overlap for 0.56 miles along Elm Street in Hampton.
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U.S. 601 turns north from U.S. 278/S.C. 363 (Elm Street) onto Hoover Street at the five point intersection with Mulberry Street.
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Old Salkehatchie Highway leads south to the Hampton and Branchville Railroad siding of Miley.
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Crossing the Big Salkehatchie River, U.S. 601 (Bamberg Highway) north enters Colleton County.
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U.S. 601 (Broxton Bridge Highway) passes through western Colleton County for 4.65 miles before entering Bamberg County.
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U.S. 601 (Broxton Bridge Road) north converges with U.S. 301 (Main Highway) just outside the city of Bamberg.
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U.S. 301 travels southwest from Bamberg to Allendale.
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